Research Progress of Traditional Chinese Medicine Intervention in Malignant Tumor Metastasis Based on Metabolic Reprogramming
10.13422/j.cnki.syfjx.20241522
- VernacularTitle:基于代谢重编程探讨中药干预恶性肿瘤转移的研究进展
- Author:
Hesheng LI
1
;
Chunchan LI
1
;
Huahui GUO
1
;
Jiasheng HUANG
1
;
Congying LAN
1
;
Penghui CHEN
1
;
Renfa HUANG
1
Author Information
1. Shenzhen Hospital， Guangzhou University of Chinese Medicine （ Futian ）， Shenzhen 518034， China
- Publication Type:Review
- Keywords:
metabolic reprogramming;
malignant tumor;
metastasis;
traditional Chinese medicine;
epithelial mesenchymal transformation （EMT）;
tumor microenvironment;
growth and metabolism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(3):272-280
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor metastasis is the key factor leading to poor prognosis of patients， and it is a difficult problem to be overcome in the field of tumor therapy. Metabolic reprogramming， as a key link in the regulation of tumor metastasis activity， affects the growth， invasion， and metastasis of tumor cells by changing the metabolic pathways of intracellular substances （such as glucose， amino acids， lipids， and nucleotides）. In particular， metabolic reprogramming plays a key role in the multistage linked steps related to tumor metastasis and can play a crucial role in several key stages of tumor tissue dissociation in situ， hematogenous metastasis， and remote colonization. Malignant tumor cells can selectively adjust their own metabolic state to adapt to the growth conditions of different metastatic microenvironments and colonization sites and then choose the most favorable growth and metabolism strategy. According to the holistic concept of traditional Chinese medicine （TCM）， the metastasis of malignant tumors is generally closely related to the metabolic state of the whole body. One of the advantages of TCM in the treatment of malignant tumors is systemic regulation. With its multi-pathway， multi-target， and multi-component therapeutic characteristics， TCM can effectively control the metastasis of malignant tumors by regulating the degradation of tumor epithelial mesenchymal transformation （EMT） and extracellular matrix （ECM）， anchoring the independent growth of tumor cells and the tumor microenvironment. In this paper， the potential regulatory effects of metabolic reprogramming on the metastasis of malignant tumors were discussed， and the latest research progress of the regulation of metabolic reprogramming by TCM on tumor metastasis was reviewed. At the same time， the key targets of TCM and its bioactive components in the process of tumor metastasis intervention were reviewed. This study aims to provide a more valuable basis and clearer idea for the treatment of malignant tumor metastasis by regulating metabolic reprogramming with TCM.
