Study on Medication Information in Drug Instructions of β-lactam Antibiotics in Children's Hospitals in Multiple Regions of China
DOI: 10.13748/j.cnki.issn1007-7693.20232249
- VernacularTitle:中国多地区儿童医院β内酰胺类抗菌药物说明书中相关儿童用药信息研究
- Author:
ZHOU Chengyue
1
,
2
;
RUAN Wenyi
1
,
2
;
WANG Zhuoyun
1
,
2
;
YAO Qi
1
,
2
;
CAI Heping
1
,
2
Author Information
1. Department of Clinical Pharmacy, Anhui Provincial Children'
2. s Hospital, Hefei 232000, China
- Publication Type:Journal Article
- Keywords:
β-lactam antibiotics / child / drug instructions / medication information
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(22):3081-3089
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT: OBJECTIVE To investigate the children's medication information in β-lactam antibiotics's in children's hospitals in multiple regions, and to provide reference for further improving the drug information in the instructions of β lactam antibiotics. METHODS Collecting 847 drug instructions of β-lactam antibiotics in twenty children's hospitals in China, medication information labeling in drug instructions on children was investigated and analyzed. RESULTS After excluding duplicates, a total of 396 antibacterial drug inserts were obtained, involving 62 varieties, including 12 penicillins(59 copies), 27 cephalosporins(201 copies), etc. But there was two antibacterial drug for children only and up to 376 drugs for children and adults. In all drugs, there were 284 injections(71.72%) and 112 oral preparations(28.28%), among which the most suitable dosage forms for children were dry suspension(24.11%), granules(23.21%) and chewable tablets(4.46%). The annotation rates of children's indication, children's usage and dosage, children's drug guidance, pharmacokinetics in children, children's adverse reactions(396 categories) were respectively 27.78%, 93.69%, 64.65%, 39.14%, 20.96%, respectively. In oral dosage forms, the labeling rate of children's indications was 32.14%, the labeling rate of children's usage and dosage was 95.53%, the labeling rate of medication items for children was 58.93%, among them there were significant differences in the precautions and adverse reaction labeling rates between oral preparation and injections(P<0.05). There was not much difference in the labeling of pediatric medication information between domestic drugs and foreign-related drugs, but there was significant difference in the information labeling of precautions(P<0.05). There was no significant difference in the labeling rate of children's medication information among the seven regional children's hospitals. CONCLUSION There are few pediatric-specific β-lactam antibiotics, and the labeling information for pediatric use in their respective instructions is often incomplete and insufficient to provide meaningful guidance. Relevant departments should pay attention to the incomplete mark of drug use for children, improve the medication information of children in the instructions, and ensure the safety of pediatric drug use.
