Investigation on the Use of Spironolactone Tablet in Children's Hospital and Thinking on the Countermeasures of Splitting
DOI:10.13748/j.cnki.issn1007-7693.20232953
- VernacularTitle:儿童医院螺内酯片使用情况调查及分剂量对策思考
- Author:
LI Yanhong
1
,
2
;
YE Junjie
1
,
2
;
HONG Chengtao
1
,
2
;
SHEN Yating
1
,
2
;
HUANG Lingfei
1
,
2
;
NI Yinghua
1
,
2
Author Information
1. Department of Pharmacy, Children'
2. s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
- Publication Type:Journal Article
- Keywords:
children / spironolactone / tablet / splitting / precision / individualization
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(22):3076-3080
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:OBJECTIVE To investigate the use of spironolactone tablet in children's hospital, and to explore the feasible scheme that can improve the current dosage distribution of spironolactone tablets, so as to meet the needs of precise and individualized clinical administration of pediatric patients. METHODS All the prescriptions including spironolactone tablet (20 mg per tablet) were obtained from 1st January 2021 to 31th December 2022 in Children's Hospital, Zhejiang University School of Medicine. The children's age, splitting specification, department distribution and problems of common tablet splitting were analyzed, appropriate countermeasures were explored according to literature and team practice. RESULTS A total of 11 239 spironolactone tablet prescriptions were included, among which, the proportion of splitting was 83.91%; in the splitting prescriptions, it showed the characteristics of young age, multi-dose specifications, strong drug specialization and long drug duration. Formulating the practice specification for manipulation of drugs, with the right dosing tool, contribute to improve the accuracy of manipulation of drugs and reduce adverse events caused by incorrect dosing; while, the exploration of extemporaneous liquid preparations and preparations in medical institutions, contributed to improve the accuracy and stability of dosing, and realize individualized drug delivery. CONCLUSION In this study, exploring the appropriate dosage regimen for spironolactone tablet as an example, feasible countermeasures with accurate fractional dose, controllable quality and high compliance of children are explored in combination with team practice and literature retrieval analysis, which is based on the actual clinical needs, so as to provide reference for finding appropriate fractional dose administration schemes for pediatric tablets.
