Exploration on the pathological mechanism of central fatigue from the correlation between liver stagnation and spleen deficiency and mitophagy
- VernacularTitle:从肝郁脾虚与线粒体自噬的相关性探讨中枢疲劳的病理机制
- Author:
Yifei ZHANG
1
;
Qingqian YU
1
;
Qinghuan SHI
1
;
Bijuan LAN
1
;
Zehan ZHANG
1
;
Feng LI
1
Author Information
- Publication Type:Journal Article
- Keywords: central fatigue; mitophagy; liver depression and spleen deficiency; oxidative stress; energy metabolism
- From: Journal of Beijing University of Traditional Chinese Medicine 2024;47(12):1661-1667
- CountryChina
- Language:Chinese
- Abstract: Central fatigue refers to the central nervous system disease caused by excessive mental pressure or excessive physical activity, which shows a series of fatigue symptoms. The pathological mechanism of central fatigue remains unclear, and the mitochondrial quality control pathway represented by mitophagy is closely related to the occurrence and development of central fatigue. Traditional Chinese medicine considers liver stagnation and spleen deficiency as the key pathogenesis of central fatigue. This paper suggests that oxidative stress may be an important basis for the occurrence of central fatigue, energy metabolism disorders are specific manifestations of liver′s failure of conveyance and dispersion and spleen′s failure of healthy transportation, and the abnormal accumulation of reactive oxygen can be regarded as pathological products of central fatigue. Therefore, based on oxidative stress and energy metabolism, the pathologic mechanism of liver′s failure of conveyance and dispersion and spleen′s failure of healthy transportation in central fatigue from the perspective of mitophagy has a rich theoretical connotation, and provides a theoretical reference for the clinical treatment of central fatigue.
- Full text:2025010216363727884Exploration on the pathological mechanism of central fatigue from the correlation between liver stagnation and spleen deficiency and mitophagy.pdf
