Axillary hyperpigmentation is a common cosmetic concern among females of dark skin types. It can affect quality of life and self-esteem of individuals. Currently, there is no standard treatment for axillary hyperpigmentation. Topical and laser therapeutics have been used with variable effectiveness, course and duration of treatment. To date, there are no reported studies using the combination of lasers and topical medications.

The main objective of this study is to determine the effectiveness and safety of Nd:YAG laser with topical niacinamide in reducing axillary hyperpigmentation.

This was a 20-week, single center, randomized controlled trial that compared the effectiveness of topical niacinamide (group 1), Nd:YAG laser (group 2), and Nd:YAG laser with topical niacinamide (group 3) in reducing axillary hyperpigmentation. Assessment of axillary hyperpigmentation was done according to luminosity difference using Von Luschan’s Chromatic classification scale. Clinical improvement was assessed using Global Aesthetic Improvement Scales (GAIS). Patient satisfaction and adverse effects were noted on follow up visits every 4 weeks.

All 3 treatment groups showed reduction in axillary hyperpigmentation based on significant decrease in median luminosity difference (p valuesCONCLUSION

Q-switch Nd: YAG laser with topical niacinamide is an effective and safe treatment option in reduction of axillary hyperpigmentation.