In recent years, there has been a significant global increase in skin cancer incidence, which continues to pose a significant challenge to public health. This retrospective study aimed to comprehensively characterize the epidemiology of histopathologically diagnosed skin cancers at the Department of Dermatology, Jose R. Reyes Memorial Medical Center from January 2013 to December 2022. The research encompassed an analysis of demographic and clinical profiles in 352 cases. The cases consisted of basal cell carcinoma (BCC) (161, 46%), squamous cell carcinoma (SCC) (62, 18%), melanoma (21, 6%), mycosis fungoides (MF) (37, 11%), other cutaneous T-Cell lymphomas (11, 3%), mammary Paget’s disease (7, 2%), extramammary Paget’s disease (6, 1.7%), Langerhans cell histiocytosis (LCH) (8, 2%), sebaceous carcinoma (3, 1%), Merkel cell carcinoma (MCC) (1, 0.3%), dermatofibrosarcoma protuberans (1, 0.3%), angiosarcoma (2, 0.6%), Kaposi sarcoma (3, 0.9%), and cutaneous metastasis (29, 8%). Among the primary cutaneous malignancies, BCC, SCC, MF, and melanoma were the most frequently encountered types. The findings reveal a notable upward trend in all skin cancer incidence, and projections suggest a continued increase in the next five years. BCC and SCC were more common in males and affected predominantly sun-exposed areas, while melanoma exhibited a slight female preponderance and primarily affected the lower extremities (acral melanoma). These skin cancers were more common among elderly individuals. The study highlights the need for standardized documentation to improve data quality on epidemiology. This, in turn, can lead to improved early detection, prevention, and better management of this escalating global public health issue.