Acute generalized exanthematous pustulosis overlapping Stevens-Johnson Syndrome in a 53-year-old Filipino female: A case report
- Author:
Hans Elmund F. Alitin
;
Jamaine Melisse Cruz-Regalado
;
Andrea Marie Bernales-Mendoza
;
Vilma C. Ramilo
- Publication Type:Case Reports
- Keywords: Acute Generalized Exanthematous Pustulosis-stevens-johnson Syndrome Overlap; Sjs/ten
- MeSH: Human; Female; Middle Aged: 45-64 Yrs Old; Acute Generalized Exanthematous Pustulosis; Stevens-johnson Syndrome
- From: Journal of the Philippine Dermatological Society 2024;33(Suppl 1):12-12
- CountryPhilippines
- Language:English
-
Abstract:
Acute generalized exanthematous pustulosis (AGEP) and Stevens-Johnson Syndrome (SJS) are uncommon, severe cutaneous drug eruptions with distinct clinical and histopathological features. AGEP-SJS overlap is a rare and complicated cutaneous drug eruption. Neutrophilia, leukocytosis, and elevated liver enzymes can be seen in these patients. Currently, there are no available dermoscopic studies on AGEP overlapping SJS. The pathophysiology of overlapping drug reaction are mediated by T cells and delayed-type hypersensitivity. Management includes removal of offending drug and giving supportive measures like pain management, moist dressing and fluids.