Non-invasive pressure-strain loop technology for early detection of left ventricular systolic dysfunction in patients with chronic kidney disease
10.12025/j.issn.1008-6358.2024.20240404
- VernacularTitle:无创压力-应变环技术在早期发现慢性肾脏病患者左心室收缩功能损伤中的价值
- Author:
Huiping HOU
1
,
2
,
3
;
Zhihong CHEN
4
;
Qiaoyan WU
1
,
2
,
3
;
Zehan XIE
1
,
2
,
3
;
Yongshi WANG
1
,
2
,
5
,
6
;
Limin LUO
1
,
2
,
3
Author Information
1. Department of Echocardiography, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen 361015, Fujian, China
2. Xiamen Clinical Research Center for Medical Imaging, Xiamen 361015, Fujian, China
3. Xiamen Clinical Research Center for Cancer Therapy, Xiamen 361015, Fujian, China.
4. Department of Nephrology, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen 361015, Fujian, China.
5. Xiamen Clinical Research Center for Cancer Therapy, Xiamen 361015, Fujian, China
6. Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
- Publication Type:Shortarticle
- Keywords:
chronic kidney disease;
pressure-strain loop;
myocardial work;
left ventricular systolic function
- From:
Chinese Journal of Clinical Medicine
2024;31(6):898-904
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of the global myocardial work parameters in the non-invasive pressure-strain loop (PSL) technology for early assessment of left ventricular systolic function in patients with chronic kidney disease (CKD). Methods A retrospective analysis was performed on 74 patients with normal left ventricular ejection fraction (LVEF) who were hospitalized in the Nephrology Department of Zhongshan Hospital (Xiamen Branch), Fudan University, from August 2021 to December 2021. Based on CKD stages, patients were divided into early group (CKD stages 1-3) and advanced group (CKD stages 4-5). Additionally, 30 healthy volunteers matched for age and gender were selected as the control group. General clinical data, routine left ventricular ultrasound indicators, myocardial strain, and global myocardial work parameters were collected and compared among the three groups. Correlation analysis and multiple linear regression were used to assess the influencing factors of myocardial work. Results There were no statistically significant differences in global work index (GWI) and global constructive work (GCW) among the three groups. Compared to the control group, both CKD groups showed significantly reduced global work efficiency (GWE), along with significantly increased global waste work (GWW, P＜0.05). The absolute value of global longitudinal strain (GLS) in the advanced CKD group (n＝42) was significantly lower than that in the early CKD group (n＝32; [﹣17.09±0.82]% vs [﹣18.33±0.90]%, P＜0.05), and GWE was also significantly lower (93.00%[90.00%, 95.00%] vs 96.00%[92.25%, 96.75%], P＜0.05), while GWW was significantly higher than that in the early CKD group (150.00 mmHg%[105.25 mmHg%, 215.00 mmHg%] vs 88.00 mmHg%[64.25 mmHg%, 144.50 mmHg%], P＜0.05). Correlation analysis showed that GWE was negatively correlated with the absolute value of GLS and peak strain dispersion (PSD; r＝﹣0.396, ﹣0.558, P＜0.05), GWW was positively correlated with absolute value of GLS, and PSD (r＝0.341, 0.610, P＜0.01). Multiple linear regression results indicated that PSD was an independent influencing factor for GWE (β＝﹣0.558, P＜0.001) and GWW (β＝0.538, P＜0.001). Conclusions The myocardial work parameters GWE and GWW in non-invasive left ventricular PSL technology can identify subclinical left ventricular systolic dysfunction in patients with CKD early and quantitatively.
