Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria

Yiqi Zhu; Yixin Shao; Duoqin Wang; Yanyun Shen; Taiyu Jin; Lisi Peng; Hui Tang; Zijing Xiao

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Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria

VernacularTitle:Mas相关G蛋白偶联受体X2及白介素与慢性自发性荨麻疹的相关性
Author: Yiqi ZHU ¹ ; Yixin SHAO ¹ ; Duoqin WANG ¹ ; Yanyun SHEN ¹ ; Taiyu JIN ¹ ; Lisi PENG ¹ ; Hui TANG ¹ ; Zijing XIAO ¹
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1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Publication Type:Originalarticle
Keywords: chronic spontaneous urticaria; disease severity; Mas-related G protein-coupled receptor X2; interleukin-23
From: Chinese Journal of Clinical Medicine 2024;31(6):875-882
CountryChina
Language:Chinese
Abstract: Objective To explore the correlations between serum Mas-related G protein-coupled receptor X2 (MRGPRX2), interleukin (IL)-4, IL-5, IL-6, IL-13, IL-23 and IL-33 levels and chronic spontaneous urticaria (CSU). Methods The clinical characteristics and laboratory data from 55 patients with CSU and 21 healthy controls at Huashan Hospital, Fudan University from February 2021 to September 2023 were collected. The disease activity and severity of CSU patients were assessed. Serum level of MRGPRX2 was tested using enzyme-linked immunosorbent assay (ELISA), and levels of IL-4, IL-5, IL-6, IL-13, IL-23, and IL-33 were measured using Luminex multiplex assay in all subjects. Spearman correlation analysis was used to evaluate the correlations between biomarkers and other parameters in CSU patients, and logistic regression analysis was performed to identify factors influencing CSU. Results CSU patients exhibited significantly higher serum levels of MRGPRX2 (2.41[0, 11.51] ng/mL vs 0[0, 2.86] ng/mL, P＝0.015) and IL-23 (0.09[0.04, 0.56] pg/mL vs 0.05[0.03, 0.08] pg/mL, P＝0.033) than healthy controls. There was no difference in levels of other cytokines between the two groups. There was no difference in levels of MRGPRX2 and cytokines between severe and non-severe CSU patients. Correlation analysis showed that serum MRGPRX2 levels in CSU patients were positively correlated with IL-4 (r＝0.345, P＝0.010) and IL-6 (r＝0.395, P＝0.003) levels. Logistic regression analysis indicated that MRGPRX2≥0.055 ng/mL and IL-23≥0.135 pg/mL were independent risk factors for CSU (P＜0.05). Conclusions Serum levels of MRGPRX2 and IL-23 in CSU patients are elevated, which may be involved in the pathogenesis of CSU.