Insulin effect on bupivacaine-induced cardiotoxicity in rabbits.
10.4097/kjae.2011.61.6.493
- Author:
Yun Suk CHOI
1
;
Kook Hyun LEE
Author Information
1. Deparment of Anesthesiology and Pain Medicine, Jeju National University Hospital, Jeju, Korea.
- Publication Type:Original Article
- Keywords:
Bupivacaine;
Cardiac arrhythmia;
Insulin
- MeSH:
Animals;
Arrhythmias, Cardiac;
Bupivacaine;
Contracts;
Heart Rate;
Insulin;
Rabbits;
Resuscitation
- From:Korean Journal of Anesthesiology
2011;61(6):493-498
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractory to conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-induced cardiovascular collapse in pentobarbital-anesthetized rabbits. METHODS: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolus of regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulin group (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8). RESULTS: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10 minutes after the BIE in the insulin group. CONCLUSIONS: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection, probably through facilitation of cardiac conduction and contraction.
