Interventional effects of ginsenoside in pyroptosis and its potential for the treatment of diabetic nephropathy
- VernacularTitle:人参皂苷对细胞焦亡的干预作用及在糖尿病肾病中的治疗潜力
- Author:
Yuan WEI
1
;
Enchao ZHOU
1
Author Information
1. Dept. of Neurology，Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210029，China
- Publication Type:Journal Article
- From:
China Pharmacy
2024;35(24):3087-3092
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy （DN） is a common complication of diabetes and the leading cause of end-stage renal disease. Pyroptosis is a mode of programmed cell death that plays an important role in the development of DN. Pyroptosis of podocytes， glomerular endothelial cells and tubular epithelial cells leads to renal injury and dysfunction， accelerating the progression of DN. In recent years， studies have shown that a variety of ginsenosides have the potential to inhibit pyroptosis-related pathways， providing new ideas for DN treatment. Among them， ginsenoside compound K， ginsenoside Rg5， ginsenoside Rg1， ginsenoside Rh2 and ginsenoside Rb1 exert a protective effect against DN by regulating nucleotide-binding domain-rich repeat and pyrin domain- containing protein 3 inflammatory vesicle pathway， such as caspase-1， nuclear factor-κB， gasdermin D-N， interleukin-1β （IL-1β） and IL-18， thereby inhibiting inflammation and cellular pyroptosis. However， most current studies have focused on animal models， and further clinical trials are needed to verify the efficacy and safety of ginsenosides in humans. In addition， future studies need to explore the differences in response to ginsenosides in different individuals and the fine-tuning mechanism of ginsenosides against the cellular pyroptosis pathway to optimize therapeutic efficacy and reduce potential side effects.
