Real-world research on Panlongqi tablets in the treatment of fractures
- VernacularTitle:盘龙七片治疗骨折的真实世界研究
- Author:
Shiyuan FANG
1
;
Jian QIN
2
;
Liyong ZHANG
3
;
Zerong WU
4
;
Tuanmao GUO
5
;
Ting DONG
6
;
Wei XU
1
;
Jiazhao YANG
1
;
Lei CHEN
7
;
Bin LIU
1
Author Information
1. Dept. of Orthopedic Trauma，the First Affiliated Hospital of USTC （Anhui Provincial Hospital），Hefei 230001，China
2. Dept. of Orthopedics，Sir Run Run Hospital，Nanjing Medical University，Nanjing 211198，China
3. Trauma Center，Yangzhou Hospital of TCM，Jiangsu Yangzhou 225100，China
4. Dept. of Orthopedics and Traumatology，Shenzhen Bao’an Traditional Chinese Medicine Hospital，Guangdong Shenzhen 518100，China
5. Dept. of Medical Laboratory，Xianyang Central Hospital，Shaanxi Xianyang 712000，China
6. Dept. of Orthopedics and Traumatology，Hangzhou Fuyang Traditional Chinese Medicine Orthopedic Hospital，Hangzhou 311499，China
7. School of International Pharmaceutical Business，China Pharmaceutical University，Nanjiang 211100，China
- Publication Type:Journal Article
- Keywords:
Panlongqi tablets;
real-world research;
fracture;
propensity matching score method
- From:
China Pharmacy
2024;35(24):3046-3051
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the effectiveness and safety of Panlongqi tablets in the treatment of fractures based on real-world research. METHODS From September 2021 to September 2023， fracture patients admitted to 33 medical institutions were collected retrospectively. Patients who received conventional treatment were divided into control group （n＝3 750）， and patients who received combination of Panlongqi tablets on the basis of conventional treatment were divided into observation group （n＝ 3 706）. Self-reported indicators of patients were collected through telephone follow-up at 0， 4， 7 and 14 days after treatment. The improvement values of pain score， swelling score and health utility value， as well as effective rate and adverse drug reactions were compared between 2 groups. The propensity matching score （PSM） method was adopted to perform baseline matching on patient’s age， gender， fracture site， fracture severity， surgical type， type of hospital， and other indicators. Statistical analysis was performed on each therapeutic effect indicator. RESULTS After PSM， a total of 6 425 patients were included， of which 3 055 were in the observation group and 3 370 were in the control group. After 14 days of treatment， the observation group showed significant improvement in pain score （4.768 vs. 4.353）， swelling fangshiyuan2008@126.com grading score （2.979 vs. 2.391）， and life quality utility value （0.430 vs. 0.363）， as well as effective rate （87.20% vs.75.99%） compared to the control group （P＜0.05）. The results of subgroup analyses conducted by gender， age， hospital type， and fracture site were consistent with the aforementioned results. In terms of safety， the observation group had no serious adverse reactions， with a total of 29 cases of mild adverse reactions such as dizziness， stomach pain， and allergies， with an incidence rate of 0.78%. CONCLUSIONS Panlongqi tablets combined with conventional treatment are significantly better than conventional treatment in improving pain， swelling， quality of life， and effective rate in patients with fractures， and have good safety.
