Research progress on function of phosphatase 1 nuclear targeting subunit(PNUTS) in tumorigenesis
10.13200/j.cnki.cjb.004387
- VernacularTitle:蛋白磷酸酶1核靶向亚基在肿瘤形成中作用的研究进展
- Author:
ZHENG Jiahao
- Publication Type:Journal Article
- Keywords:
Phosphatase 1(PP1);
Phosphatase 1 nuclear targeting subunit(PNUTS);
Oncocytes;
Phosphorylation
- From:
Chinese Journal of Biologicals
2024;37(12):1524-1528+1536
- CountryChina
- Language:Chinese
-
Abstract:
There are more than 200 regulatory subunits of protein phosphatase 1(PP1), among which phosphatase 1 nuclear targeting subunits(PNUTS) are involved in the dephosphorylation process of PP1, regulate the activity and subcellular localization of PP1, and can also regulate the cell cycle process and centrosome maturation and division by binding to specific regulatory proteins. PNUTS can regulate the functions of many proteins related to tumorigenesis, for example, bind to oncogene MYC to regulate its transcription function, and bind to tumor suppressor phosphatase and tensin homolog(PTEN) to inhibit its negative regulation on PI3K-AKT signaling pathway. In addition, PNUTS are also related to the cell apoptosis mediated by Caspase protein family. In this paper, the structure of PNUTS and the role in tumorigenesis are reviewed in order to provide a reference for finding new targets for tumor treatment.
