YAP expression in non-cardia gastric cancer and the relationship with its single nucleotide polymorphisms
10.19405/j.cnki.issn1000-1492.2022.09.030
- Author:
Licong Ma
1
,
2
;
Xuyang Tian
1
,
2
;
Deli Liu
3
;
Xuefeng Bai
4
;
Yanbin Jia
5
,
6
,
7
Author Information
1. The Pathology Department , The Second Afiliated Hospital of Baotou Medical College ,Baotou 014030
2. Inner Mongolia Institute of Digestive Diseases , The Second Afiliated Hospital of Baotou Medical College ,Baotou 014030
3. School of Basic Medicine and Forensic Medicine , Baotou Medical College ,Baotou 014060
4. The Pathology Department ,Baotou Cancer Hospital ,Baotou 014030
5. Inner Mongolia Institute of Digestive Diseases , The Second Afiliated Hospital of Baotou Medical College ,Baotou 014030
6. School of Basic Medicine and Forensic Medicine , Baotou Medical College ,Baotou 014060
7. School of Nursing ,Baotou Medical College ,Baotou 014060
- Publication Type:Journal Article
- Keywords:
Yes⁃associated protein;
non⁃cardia gastric cancer;
protein expression;
single nucleotide polymorphism;
association study
- From:
Acta Universitatis Medicinalis Anhui
2022;57(9):1499-1503
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the differences in the expression of Yes-associated protein(YAP) in non-cardia gastric cancer and normal gastric tissue and analyze the associations between single nucleotide polymorphisms(SNP) in the YAP gene andits protein expression,and to preliminarily discuss the correlationbetween YAP and the development of non-cardia gastric cancer,so as to provide new ideas for the prevention and treatment of non-cardia gastric cancer.
Methods:126 casesofnon-cardia gastric cancer tissues and 104 cases of paracancerous normal tissues were collected and set as case group and control group,respectively. Immunohistochemical SP assay was used to detect the expression of YAP in non-cardia gastric cancer tissues and adjacent normal tissues. Taqman method was used for genotyping. The unconditional logistic regression method was used to calculate the odds ratio(OR) and its 95%confidence interval(CI) to detect the associations between YAP SNPs and the expression of YAP protein under Codominant,Dominant,Overdominant,Recessive,and Log-additive genetic models.
Results:The expression of YAP protein in non-cardia gastric cancer tissues was significantly higher than that in normal gastric tissues(P<0. 001).The expression level of YAP protein was negatively correlated with the degree of tumor differentiation(P<0. 05).There was no correlationbetween the expression level of YAP protein and gender,age,lymph node metastasis and tumor size respectively(P>0. 05). No associations were found between SNP rs11225163 and rs1820453 and the expression of YAP protein under Codominant,Dominant,Overdominant,Recessive and Log-additive genetic models.Haplotype was constructed by Haploview 4. 2 software,and the association between haplotype and YAP protein expression was analyzed.
Conclusion :YAP may be involved in the development of non-cardia gastric cancer.
- Full text:202412271618554301YAP在非贲门胃癌的表达及...态性与YAP表达水平的关系_马立聪.pdf
