The influential factors on tumor diameters in rectal cancer analyzed with generalized additive model
10.19405/j.cnki.issn1000-1492.2022.09.029
- Author:
Long Xu
1
;
Shengyi Wang
1
;
Zhen Zhang
1
Author Information
1. Dept of General Surgery, The First Afiliated Hospital of Anhui Medical University,Hefei 230022
- Publication Type:Journal Article
- Keywords:
rectal neoplasms;
tumor diameter;
generalized additive model;
locally weighted scatterplot smoothing;
carcinoembryonic antigen;
blood platelets;
T stage
- From:
Acta Universitatis Medicinalis Anhui
2022;57(9):1494-1498
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influential factors on tumor diameters in rectal cancer.
Methods :Cross sectional study data were collected from patients undergoing radical resection of rectal cancer.Patients were grouped by median value of tumor diameter, and the clinical pathological characteristics were compared between the two groups.The associations between tumor diameter and continuous variables were analyzed using locally weighted scatterplot smoothing(LOWESS) method.The associating factors of tumor diameter were further analyzed using generalized additive model(GAM).
Results : Patients with rectal cancer were divided into two groups with tumor diameter either<4 centimeters or ≥4 centimeters.Proportions of T,TNM stages differed significantly between different groups.Median carcinoembryonic antigen(CEA) in≥4 centimeters group were 4.90 ng/ml(inter-quartile range [IQR] 2.39,9.53 ng/ml),much higher than that in<4 centimeters group(2.93 ng/ml [IQR:1.78,4.90 ng/ml]),P<0.01.LOWESS analysis showed that there were non-linear relationships between tumor diameter and the following variables: age, the distance between tumor and anal verge, CEA,neutrophils, lymphocytes, platelets, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio.GAM showed that increased blood platelets(P<0.05) and later T stage(P<0.01) were significantly associated with increased tumor diameters, and increased CEA levels were also associated with larger tumors(P<0.01),but there were saturation effects.
Conclusion:Platelets, T stage and CEA are associated with tumor diameter in rectal cancer, indicating that the above factors should be considered when studying associated factors of tumor diameter in rectal cancer.
- Full text:2024122715513977874直肠癌肿瘤直径影响因素的广义相加模型分析_徐龙.pdf
