Analysis of pathogenesis evolution and therapeutic strategies for"inflammation-cancer transformation"in chronic pancreatitis based on"state-target-cause-result"
10.3969/j.issn.1006-2157.2024.10.005
- VernacularTitle:基于"态靶因果"探析慢性胰腺炎"炎癌转化"的病机演变与论治策略
- Author:
Yunfei DAI
1
,
2
;
Dong SHANG
;
Hong XIANG
;
Xi GUAN
;
Liang ZHAO
;
Changchuan BAI
Author Information
1. 大连医科大学附属第一医院 大连 116011
2. 大连医科大学中西医结合研究院/学院
- Keywords:
state-target-cause-result;
chronic pancreatitis;
inflammation-cancer transformation;
pancreatic cancer;
preventive treatment of disease
- From:
Journal of Beijing University of Traditional Chinese Medicine
2024;47(10):1360-1366
- CountryChina
- Language:Chinese
-
Abstract:
"State-target-cause-result"is a new clinical theory combining macroscopic and microscopic syndrome differentiation based on the holistic view of traditional Chinese medicine combined with Western medical research.The"inflammation-cancer transformation"of chronic pancreatitis is a complex pathological process that is associated with the interaction between the pancreas and various pathological factors and multiple objects,involving the imbalance of multiple homeostasis.The microscopic process of"inflammation-cancer transformation"in chronic pancreatitis is the"target,"whereas various factors that could induce its occurrence under chronic inflammatory conditions are the"state."The"inflammation-cancer transformation"of chronic pancreatitis is summarized as yin and yang imbalance,qi movement disorder,endogenous dampness,heat,blood stasis,and turbid phlegm stagnation,unresolved congestion resulting in deficiency caused by stagnation,intermingled deficiency and excess,and internal cancer toxin generation.This paper elucidates the pathogenesis and intervention strategies of the"inflammation-cancer transformation"of chronic pancreatitis from a macro perspective of"state,"focusing on reducing the impact of"state"imbalance on the"target"to establish a balanced pancreas-immune-microbiota state.The aim is to broaden the theory for exploring the mechanism and drug development related to chronic pancreatitis"inflammation-cancer transformation"in both traditional Chinese and Western medicine.
- Full text:2024122616162133178Analysis of pathogenesis evolution and therapeutic strategies for “inflammation-cancer transformation” in chronic pancreatitis based on “state-target-cause-result”.pdf
