The characteristic analysis of lipid metabolism and intestinal flora in platinum-resistant ovarian cancer at stage Ⅲ-Ⅳ based on the theory of"tumour toxicity"in traditional Chinese medicine
10.19405/j.cnki.issn1000-1492.2024.10.024
- VernacularTitle:基于中医"瘤毒内生"理论探讨Ⅲ-Ⅳ期铂耐药卵巢癌脂代谢与肠道菌群的特征
- Author:
Haili JIANG
1
,
2
;
Yingquan YE
;
Die HU
;
Rui SHENG
;
Chaozheng GAO
;
Shuqi ZHAN
;
Mei ZHANG
;
Ting WANG
Author Information
1. 安徽医科大学第一附属医院中西医结合肿瘤科,合肥 230022
2. 安徽医科大学中西医结合肿瘤中心,合肥 230032
- Keywords:
ovarian cancer;
platinum-sensitive;
platinum-resistant;
gut microbiota;
lipid metabolism
- From:
Acta Universitatis Medicinalis Anhui
2024;59(10):1863-1870
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the differences in lipid metabolism between platinum-resistant and platinum-sensitive ovarian cancer patients at stage Ⅲ-Ⅳ,to analyze the differential intestinal flora using 16S rRNA sequen-cing,and to explore the associations among intestinal flora,lipid metabolism characteristics and platinum resistance in ovarian cancer.Methods Patients diagnosed with ovarian cancer at stage Ⅲ-Ⅳ through surgical pathology were selected,including a platinum-resistant group(11 cases)and a platinum-sensitive group(11 cases).The differences in lipid metabolism between the two groups were compared.The differences in gut microbiota between the two groups were investigated using fecal 16S rRNA sequencing.The association among gut microbiota,lipid metabolism characteristics,and platinum resistance in ovarian cancer was analyzed.Results Significant differ-ences were observed in lipid metabolism-related indicators[total cholesterol(TC),high-density lipoprotein choles-terol(HDL-C),non-high-density lipoprotein cholesterol(n-HDL),low-density lipoprotein cholesterol(LDL-C),apolipoprotein(B)]between the two groups,with higher levels in the platinum-resistant group.The Shannon in-dex(P=0.008 3)and Simpson index(P=0.008 2)both showed higher diversity of gut microbiota in platinum-resistant ovarian cancer patients compared to the platinum-sensitive group.However,based on OTUs species clus-tering and relative abundance statistics,certain bacterial abundances differed significantly between the groups.Spe-cies such as Parabacteroides,Akkermansia,Blautia,Lachnoclostridium,Fusicatenibacter,and Megamonas had sig-nificantly higher abundances in the platinum-sensitive ovarian cancer group,and Akkermansia(a lipid metabolism-related bacterial group)was the most prevalent.Conclusion The platinum-resistant group of ovarian cancer ex-hibits significantly higher levels of lipid metabolism and gut microbiota diversity compared to the platinum-sensitive group.This suggests that the increase in lipid metabolism levels and fecal microbiota diversity may be associated with the development of platinum resistance.However,certain microbial taxa are reduced in abundance in the plat-inum-resistant group,such as the distinct Akkermansia genus(a lipid metabolism-related microbial community),which may serve as one of the factors inducing platinum-resistance in ovarian cancer.
- Full text:202412260045308796基于中医“瘤毒内生”理论探...巢癌脂代谢与肠道菌群的特征_江海丽.pdf
