New insights into the relationship between Sjogren's syndrome and primary biliary cholangitis and abnormal liver function:a Mendelian randomization study
10.19405/j.cnki.issn1000-1492.2024.10.023
- VernacularTitle:对于干燥综合征与原发性胆汁性胆管炎以及肝功能异常关系的新见解:一项孟德尔随机化研究
- Author:
Lihan ZHOU
1
;
Jun XU
;
Sheng GUO
;
Yixue LI
;
Zihao XU
;
Liangbin CHENG
Author Information
1. 湖北中医药大学中医临床学院,武汉 430061
- Keywords:
Mendelian randomization;
causal relationship;
primary biliary cholangitis;
Sjogren's syndrome;
abnor-mal liver function
- From:
Acta Universitatis Medicinalis Anhui
2024;59(10):1856-1862
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the causal relationship between Sjogren's syndrome(SS)and primary biliary cholangitis(PBC)and abnormal liver function by two-sample Mendelian randomization.Methods From the ge-nome-wide association study,single nucleotide polymorphisms of SS,PBC,alkaline phosphatase,alanine amin-otransferase,aspartate aminotransferase,γ-glutamyltransferase,direct bilirubin and total bilirubin levels were extrac-ted as instrumental variables.Inverse-variance weighted(IVW)analysis was used as the main analysis,supplemen-ted by weighted median,MR-Egger,weighted mode,and simple mode.And a series of sensitivity analyses were car-ried out to verify the robustness of the results.Results The IVW analysis results of PBC on SS were as follows:P=8.57E-11,OR=1.185 9,95％CI=1.126 4-1.248 5;IVW analysis of PBC on SS(P＞0.05).IVW analysis results of SS on alkaline phosphatase were as follows:P=0.041 5,Beta=-0.007 2,95％CI=-0.014 0--0.000 3;IVW analysis results of SS on alanine aminotransferase,aspartate aminotransferase,γ-glutamyltransferase,direct bilirubin,total bilirubin levels showed no statistically significant difference.Conclusion PBC can significantly increase the risk of SS,but SS cannot be proved to have a causal effect on the occurrence of PBC.SS has a potential effect on re-ducing alkaline phosphatase levels,but it is not proved that SS has causal relationship with alanine aminotransferase,aspartate aminotransferase,γ-glutamyltransferase,direct bilirubin,total bilirubin levels.
