Survival time and influencing factors analysis of clinically diagnosed sporadic Creutzfeldt-Jakob disease patients in China from 2020 to 2022
10.19405/j.cnki.issn1000-1492.2024.10.021
- VernacularTitle:2020-2022年中国临床诊断散发型克雅病患者的生存时间及影响因素分析
- Author:
Weiwei ZHANG
1
,
2
;
Donglin LIANG
;
Donghua ZHOU
;
Yuan WANG
;
Kang XIAO
;
Wei ZHOU
;
Xiaoping DONG
;
Qi SHI
Author Information
1. 华北理工大学公共卫生学院,唐山 063210
2. 中国疾病预防控制中心病毒病预防控制所,传染病溯源预警与智能决策全国重点实验室,北京 102206
- Keywords:
sporadic Creutzfeldt-Jakob disease;
Prion;
survival analysis;
influencing factors;
Cox proportional haz-ards regression model
- From:
Acta Universitatis Medicinalis Anhui
2024;59(10):1842-1848
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the survival time of patients diagnosed with sporadic Creutzfeldt-Jakob disease in China between 2020 and 2022 and explore the associated factors influencing survival.Methods A retrospective analysis was conducted on clinically diagnosed cases with complete information on sporadic Creutzfeldt-Jakob dis-ease diagnosed by the China Creutzfeldt-Jakob disease surveillance network from 2020 to 2022,baseline information of patients was obtained from the case files,telephone follow-up was used to obtain the treatment and survival status of the patients after the diagnosis,life-table method was used for estimating the survival rate,Kaplan-Meier method was used for calculating the median survival time and the 95％CI,Cox regression model was used for univariate and multivariate analyses were used to screen for factors influencing survival time.Results The median survival time of the 300 patients was 5 months(95％CI:4.165-5.835).Univariate analysis revealed that factors such as age at onset,regional distribution,presence of corticobasal or extrapyramidal symptoms as initial manifestations,number of initial symptoms,presence of corticobasal or extrapyramidal functional abnormalities,number of major clinical manifestations,presence of typical electroencephalogram findings,and use of nasal feeding during the course of the disease were potential factors influencing survival time(P＜0.1).Multivariate analysis showed that the risk of death in patients with onset age＞65 years was 1.350 times higher than in patients with onset age ≤65 years(P=0.021,95.0％CI:1.046-1.742).Patients without pyramidal or extrapyramidal dysfunction had a 0.674-fold lower risk of death compared to those with these symptoms(P=0.020,95.0％CI:0.483-0.939).Patients who did not receive nasal feeding had a 1.817-fold higher risk of death compared to those who did(P＜0.001,95.0％CI:1.406-2.349).Conclusion Age at onset,the presence of pyramidal or extrapyramidal functional abnormalities,and the use of nasal feeding during the disease course are factors influencing the survival time of pa-tients clinically diagnosed with sCJD.
- Full text:20241226002120252262020—2022年中国临...者的生存时间及影响因素分析_张卫卫.pdf
