The expression of CD155 in oral squamous cell carcinoma tissues and its effects on migration,proliferation and invasion
10.19405/j.cnki.issn1000-1492.2024.10.009
- VernacularTitle:CD155在口腔鳞癌组织中的表达及对细胞迁移、增殖和侵袭的影响
- Author:
Jiajia ZHANG
1
;
Aimaier AIERFATI
;
Chaojie GUO
;
Huiyu WANG
;
Taoli FANG
;
Jiang XU
Author Information
1. 石河子大学第一附属医院口腔科,石河子 832000
- Keywords:
oral squamous cell carcinoma;
CD155;
cellular migration;
cellular proliferation;
cellular invasion
- From:
Acta Universitatis Medicinalis Anhui
2024;59(10):1752-1759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of CD155 in oral squamous cell carci-noma(OSCC)tissues,as well as its impact on migration,proliferation and invasion.Methods Immunohisto-chemistry(IHC)was used to analyze the expression of CD155 in OSCC tissues and its correlation with clinicopath-ological features and prognosis.The transcription levels of CD155 were assessed by Western blot and RT-qPCR.Cell experiments were conducted to evaluate the effects of CD155 on OSCC cells following transfection with CD155 siRNA.Results CD155 was predominantly expressed on the cell membrane in OSCC tissues,with higher expres-sion levels compared to normal tissues(x2=50.750,P＜0.000 1).High CD155 expression was associated withⅢ+Ⅳ disease stages(x2=25.488,P=0.001),poor differentiation(x2=6.299,P=0.012),T3+T4 depth of invasion(x2=23.820,P=0.001)and lymph node metastasis(x2=7.830,P=0.005)in OSCC patients;survival analysis revealed a correlation between high CD155 expression and shorter patient survival(P＜0.05).COX regression analysis identified lymph node metastasis as an independent factor affecting the survival of OSCC patients(P＜0.05).Both CD155 protein expression and mRNA transcription levels were significantly upregulated in OSCC cells(P＜0.05).Transfection with siRNA-CD155 in OSCC cells resulted in significantly reduced prolif-eration,migration and invasion abilities compared to the control group(P＜0.05).Conclusion CD 155 is highly expressed in OSCC tissues and is associated with poor patient prognosis.Modulating CD155 expression can influ-ence the biological functions of OSCC cells,leading to and inhibition of proliferation,migration,and invasion.
- Full text:2024122511340928174CD155在口腔鳞癌组织中...细胞迁移、增殖和侵袭的影响_张佳佳.pdf
