Advances in the study of ESRP1 in tumors

VernacularTitle:上皮剪切调控蛋白1在肿瘤中的研究进展
Author: Ruirui YANG ¹ ; Yanli LI ; Liang HE ; Bo LING ; Guangbin YE
Author Information

1. 右江民族医学院生命科学研究院,百色 533000
Keywords: ESRP1; EMT; alternative splicing; colorectal cancer; breast cancer; lung cancer
From: Acta Universitatis Medicinalis Anhui 2024;59(9):1681-1687
CountryChina
Language:Chinese
Abstract: Epithelial splicing regulatory protein 1(ESRP1)is an epithelial cell-specific splicing factor that in-volved in selective splicing and translation of multiple genes.ESRP1 regulates signaling pathways that affect cell proliferation and tumor growth via mediating target genes and regulating cyclic RNA cyclization and biogenesis in a variety of cancers,including head and neck squamous cell carcinoma,carcinoma of colon,and prostate cancer.Through integrating and analyzing the link between ESRP1 and related cancers,provide new ideas for the treatment of tumor cells in which ESRP1 as a key factor.