Dynamic evolution mechanism and treatment ideas of colorectal"inflammation-mediated carcinogenesis"based on the"latent pathogens trapped in the intestinal collaterals"theory
10.3969/j.issn.1006-2157.2024.10.002
- VernacularTitle:基于"邪伏肠络"理论探讨结直肠"炎癌转化"的动态演变机制及治疗思路
- Author:
Yunze LIU
1
;
Haocheng ZHENG
;
Yuan LI
;
Xia DING
Author Information
1. 北京中医药大学东直门医院 北京 100700
- Keywords:
colorectum;
inflammation-mediated carcinogenesis;
latent pathogens trapped in the intestinal collaterals;
intestinal collaterals;
driving away pathogenic factors and dredging the collaterals
- From:
Journal of Beijing University of Traditional Chinese Medicine
2024;47(10):1343-1348
- CountryChina
- Language:Chinese
-
Abstract:
The risk of colorectal cancer is substantially higher in patients with long-term colorectal inflammation than in the general population.Prolonged inflammation is an essential factor that triggers colorectal cancer.The dynamic pathological evolution process of the classic"inflammation-mediated carcinogenesis"in the colorectum is proctocolitis→dysplasia→cancer.Traditional Chinese medicine lacks a systematic consensus on the pathogenesis of colorectal"inflammation-mediated carcinogenesis".This article proposes the theory of"pathogenic factors lurk intestinal collaterals"to explain the development law of pathogenesis in the dynamic evolution of colorectal"inflammation-mediated carcinogenesis".Internal and external factors can trigger the movement of the latent pathogenic factors,thereby damaging the intestinal tissues,when latent pathogenic factors are hidden in the intestinal collaterals,and the healthy qi is unable to expel them.The prolonged course of the disease further weakens the healthy qi,allowing the latent pathogenic factors to accumulate in the intestinal collaterals,intertwine with phlegm-dampness and blood stasis,accelerate accumulation,and lead to cancer."Latent pathogens trapped in the intestinal collaterals"is the core pathogenesis during inflammation-mediated carcinogenesis.Thus,to prevent colorectal inflammation-mediated carcinogenesis,consideration should be given to the principle of driving away pathogenic factors and dredging the collaterals in clinical practice.The theory regarding"latent pathogens trapped in the intestinal collaterals"can provide a theoretical reference for syndrome differentiation and treating colorectal inflammation-mediated carcinogenesis and offer novel ideas for clinical treatment.
