Exploration the modern scientific connotations of traditional Chinese medicine theory and therapeutic mechanism of Chinese materia medica based on extracellular vesicles
10.3969/j.issn.1006-2157.2024.10.001
- VernacularTitle:基于细胞外囊泡阐释中医学理论现代科学内涵和中药治疗机制
- Author:
Mingjing ZHAO
1
,
2
,
3
Author Information
1. 北京中医药大学东直门医院中医内科学教育部重点实验室 北京 100700
2. 北京中医药大学心血管病研究院
3. 北京中医药大学东直门医院气血研究实验室
- Keywords:
extracellular vesicles;
traditional Chinese medicine theories;
Chinese materia medica;
Chinese herbal medicine-derived EV-like particles
- From:
Journal of Beijing University of Traditional Chinese Medicine
2024;47(10):1333-1342
- CountryChina
- Language:Chinese
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Abstract:
Extracellular vesicles(EVs)are secreted by various cells and carry information such as parent cell-derived RNA,DNA,proteins,and lipids.They mediate information exchange between cells and organs,playing a crucial role in disease occurrence and development,diagnosis,treatment,and targeted drug delivery.EVs are also closely associated with traditional Chinese medicine theories and treatments.The qi-blood-fluid and visceral outward manifestation theories are the fundamental theories of traditional Chinese medicine.EVs belong to the fluid category and can reach other viscera through the blood vessels.They regulate the relationship between the viscera or cause imbalances between the viscera,resulting in disease.Chinese materia medica,which primarily includes traditional Chinese patent medicines and simple preparations,and Chinese herbal medicine,can help regulate the quantity and content of endogenous EVs in the body to improve pathological conditions.Additionally,EV-like particles derived from herbal medicines are a major form of pharmacologically active substances that contribute to the therapeutic effects of Chinese medicine in treating diseases.Furthermore,EVs can also be used as carriers to deliver drugs for targeted therapy.Therefore,exploring the relationship between traditional Chinese medicine and EVs will elucidate the modern scientific connotation of traditional Chinese medicine theories and reveal the mechanism of Chinese materia medica.The development of engineered EVs based on Chinese materia medica will provide novel strategies for clinical treatment.
- Full text:2024122415523042152Exploration the modern scientific connotations of traditional Chinese medicine theory and therapeutic mechanism of Chinese materia medica based on extracellular vesicles.pdf
