Study on the Enhanced Transdermal Permeation of Ketoprofen Gel Induced by Ultrasound
10.13748/j.cnki.issn1007-7693.20240893
- VernacularTitle:超声导入对酮洛芬凝胶药物经皮促透效果的研究
- Author:
Xiumei JIANG
1
;
Renhua FANG
1
;
Wenxin NIU
1
;
Weiqing WANG
1
;
Yue AN
1
;
Jing YANG
2
;
Haoran WANG
3
;
Changzhao JIANG
1
;
Jincui YE
1
Author Information
1. Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou 310013, China
2. Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Huzhou 313200, China
3. Nantong University Xinglin College, Nantong 226001, China
- Publication Type:Journal Article
- Keywords:
ketoprofen gel ； ultrasound-assisted delivery ；in vitro permeation ； pharmacodynamics； pharmacokinetics
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(11):1508-1514
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To investigate the potential of low-frequency, low-power ultrasound to enhance the transdermal absorption and efficacy of ketoprofen gel.
METHODS
Ketoprofen gel was used as a model drug to compare the in vitro transdermal permeation of ultrasound treated group and untreated group. Additionally, a rat model of collagen-induced inflammation provided a basis for evaluating pharmacodynamic differences. Pharmacokinetic studies further elucidated the effects of ultrasound on ketoprofen gel's penetration process.
RESULTS
Ultrasound treatment enhanced the cumulative transdermal permeation of ketoprofen gel by 3.5-fold over 24 hours compared to untreated. Significant pharmacokinetic improvements in AUC0-t from (4289.02±763.58)ng·h·mL−1 to (11301.10±3386.30)ng·h·mL−1 and a reduction in Tmax from (6.0±1.4)h to (3.0±2.0)h. Ultrasound notably improved the gel's anti-inflammatory effects in the rat model, effectively and rapidly reducing inflammation-induced swelling.
CONCLUSION
Low-frequency, low-power ultrasound can significantly improve the amount and rate of transdermal absorption of ketoprofen gel and enhance its pharmacological potency, from the aspects of skin permeation tests, pharmacodynamic evaluation, and pharmacokinetic studies, which is an effective penetration enhancer for transdermal administration of ketoprofen gel.
