Treatment of Diabetic Kidney Disease with Active Ingredients of Astragali Radix Based on Inflammation： A Review
10.13422/j.cnki.syfjx.20241702
- VernacularTitle:基于炎症反应探讨黄芪活性成分治疗糖尿病肾脏疾病的研究进展
- Author:
Xinze YUAN
1
;
Chenchen LIU
1
;
Shengnan WANG
2
;
Xinyu SUN
1
Author Information
1. The Second Clinical Medical School，Henan University of Chinese Medicine，Zhengzhou 450002，China
2. Henan Provincial Hospital of Traditional Chinese medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
inflammation;
active ingredients of Astragali Radix;
mechanism research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(2):295-302
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is one of the common microvascular complications of diabetes mellitus （DM） and a primary cause of chronic kidney disease （CKD） and end-stage renal disease （ESRD）. Inflammation is currently a hot topic in exploring the pathogenesis of DKD. Macrophages， T cells， interleukins， tumor necrosis factor， NOD-like receptor protein 3 （NLRP3） inflammasome， Janus kinase/signal transducer and activator of transcription （JAK/STAT） signaling pathway， and nuclear factor-kappa B （NF-κB）-related signaling pathway all play a role in regulating the inflammation of DKD and accelerating its progression. Astragali Radix， a Chinese herbal medicine， is widely used in the treatment of DKD and possesses strong anti-inflammatory effects. Studies have revealed that active ingredients of Astragali Radix， including polysaccharides， astragaloside Ⅳ， total flavonoids， calycosin， and quercetin， can regulate multiple signaling pathways to ameliorate the microinflammatory state and alleviate kidney damage， thereby slowing down the progression of DKD. This article systematically reviews the factors influencing the inflammation in DKD and analyzes recent research findings and mechanisms concerning active ingredients of Astragali Radix in the management of DKD inflammation， aiming to offer novel insights and directions for the prevention， treatment， and research of DKD.
