Gualou Xiebai Banxiatang in Treatment of Cardiovascular Diseases： A Review
10.13422/j.cnki.syfjx.20242393
- VernacularTitle:瓜蒌薤白半夏汤治疗心血管疾病研究进展
- Author:
Yalong KANG
1
;
Bo NING
1
;
Juanjuan TAN
1
;
Hongfei QI
1
;
Yan SHI
1
;
Fang GUAN
1
;
Haifang WANG
1
Author Information
1. The First Clinical Medical College，Shaanxi University of Chinese Medicine，Xianyang 712046，China
- Publication Type:Journal Article
- Keywords:
Gualou Xiebai Banxiatang;
cardiovascular diseases;
clinical application;
pharmacological mechanism;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(2):256-267
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases （CVD），a group of common diseases in clinical practice，are witnessing a steady rise in both incidence and mortality rates，posing a challenge to public health. Gualou Xiebai Banxiatang，originating from Synopsis of the Golden Chamber （《金匮要略》），was initially used to treat severe cases of chest impediment. The formula consists of Trichosanthis Fructus，Allii Macrostemonis Bulbus，Pinelliae Rhizoma，and Baijiu. It has a wide range of clinical applications，with therapeutic effects including moving Qi to relieve depression，activating Yang to dissipate mass，and expelling phlegm to alleviate chest congestion. In recent years，clinical research has confirmed that Gualou Xiebai Banxiatang，with or without modification，used alone or in combination with Western medicine，has definite effects in the treatment of CVD such as hyperlipidemia，coronary atherosclerotic heart disease，hypertension，heart failure，and arrhythmia. It can alleviate disease symptoms and reduce the risk of re-hospitalization. Basic research indicates that the mechanisms of Gualou Xiebai Banxiatang include improving endothelial functions，exhibiting anti-inflammatory properties，countering oxidative stress，preventing apoptosis，inhibiting ventricular remodeling，regulating mitochondrial functions，improving hemorheology，and modulating autophagy and neurotransmitters. This article reviews relevant articles in recent years with focuses on the compatibility，clinical application，and mechanism of Gualou Xiebai Banxiatang. This review is expected to provide a theoretical basis for the mechanism research and clinical application of this formula in treating CVD and to offer ideas and reference for in-depth research.
