Mechanism of Ferroptosis in Regulating Chronic Heart Failure and Traditional Chinese Medicine Prevention and Treatment Based on Qi Deficiency and Stagnation： A Review
10.13422/j.cnki.syfjx.20242495
- VernacularTitle:基于“虚气留滞”探讨铁死亡对慢性心力衰竭的调控机制及中医药防治进展
- Author:
Ziyang YUAN
1
;
Yan ZHANG
2
;
Wei ZHANG
3
;
Yaqin WANG
1
;
Wenjun MAO
1
;
Guo YANG
1
;
Xuewei WANG
1
Author Information
1. Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China
2. The Affiliated Hospital of Liaoning University of TCM，Shenyang 110000，China
3. Shenyang Pharmaceutical University，Shenyang 110016，China
- Publication Type:Review
- Keywords:
ferroptosis;
chronic heart failure;
traditional Chinese medicine （TCM）;
Qi deficiency and stagnation;
TCM treatment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(2):248-255
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure （CHF） is the final stage of cardiovascular diseases. It is a complex syndrome， with dyspnea and edema as the main clinical manifestations， and it is characterized by complex disease conditions， difficult cure， and high mortality. Ferroptosis， a new type of programmed cell death， is different from other types of programmed cell death. Ferroptosis is iron-dependent， accompanied by lipid peroxide accumulation and mitochondrial shrinkage， becoming a hot research topic. Studies have confirmed that ferroptosis plays a key role in the occurrence and development of CHF. The regulation of ferroptosis may become a potential target for the treatment of CHF in the future. The theory of Qi deficiency and stagnation refers to the pathological state of original Qi deficiency and abnormal transportation and distribution of Qi， blood， and body fluid， which has guiding significance for revealing the pathogenesis evolution of some chronic diseases. We believe that Qi deficiency and stagnation is a summary of the pathogenesis of ferroptosis in CHF. Deficiency of Qi （heart Qi） is the root cause of CHF， and stagnation （phlegm turbidity and blood stasis） is the branch of this disease. The two influence each other in a vicious circle to promote the development of this disease. Traditional Chinese medicine （TCM） plays an important role in the treatment of CHF， improving the prognosis and quality of life of CHF patients. This paper explores the correlation between the theory of Qi deficiency and stagnation and the mechanism of ferroptosis in CHF. Furthermore， this paper reviews the mechanism of Chinese medicines and compound prescriptions in preventing and treating CHF by regulating ferroptosis according to the principles of replenishing Qi and dredging to remove stagnation， aiming to provide new ideas and methods for the treatment of CHF with TCM.
