Evaluation of Effect of Tongnaoyin on Blood-brain Barrier Injury in Acute Ischemic Stroke Patients Based on Dynamic Contrast-enhanced Magnetic Resonance Imaging
10.13422/j.cnki.syfjx.20242396
- VernacularTitle:基于DCE-MRI评价协定方通脑饮改善急性缺血性脑卒中患者血脑屏障损伤的疗效
- Author:
Yangjingyi XIA
1
;
Shanshan LI
1
;
Li LI
1
;
Xiaogang TANG
1
;
Xintong WANG
1
;
Qing ZHU
1
;
Hui JIANG
1
;
Cuiping YUAN
1
;
Yongkang LIU
1
;
Zhaoyao CHEN
1
;
Wenlei LI
1
;
Yuan ZHU
1
;
Minghua WU
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine，Jiangsu Province Hospital of Chinese Medicine，Nanjing 210029，China
- Publication Type:Journal Article
- Keywords:
acute ischemic stroke;
Tongnaoyin;
syndrome of phlegm-stasis blocking collaterals;
blood-brain barrier;
dynamic contrast-enhanced magnetic resonance imaging （DEC-MRI）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(2):140-146
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effects of Tongnaoyin on the blood-brain barrier status and neurological impairment in acute ischemic stroke （AIS） patients with the syndrome of phlegm-stasis blocking collaterals by dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI）. MethodsA total of 63 patients diagnosed with AIS in the Jiangsu Province Hospital of Chinese Medicine from October 2022 to December 2023 were enrolled in this study. According to random number table method，the patients were assigned into a control group （32 cases） and an observation group （31 cases）. The control group received conventional Western medical treatment，and the observation group took 200 mL Tongnaoyin after meals，twice a day from day 2 of admission on the basis of the treatment in the control group. After 7 days of treatment，the patients were examined by DCE-MRI. The baseline data for two groups of patients before treatment were compared. The National Institute of Health Stroke Scale （NIHSS） score and modified Rankin Scale （mRS） score were recorded before treatment and after 90 days of treatment for both groups. The rKtrans，rKep，and rVe values were obtained from the region of interest （ROI） of the infarct zone/mirror area and compared between the two groups. ResultsThere was no significant difference in the NIHSS or mRS score between the two groups before treatment. After 90 days of treatment，the NIHSS and mRS scores declined in both groups，and the observation group had lower scores than the control group （P<0.05）. After treatment，the rKtrans and rVe in the observation group were lower than those in the control group （P<0.01）. ConclusionCompared with conventional Western medical treatment alone，conventional Western medical treatment combined with Tongnaoyin accelerates the repair of the blood-brain barrier in AIS patients，thereby ameliorating neurological impairment after AIS to improve the prognosis.
