Application of eliminating flatulence and laxative cream in advanced hepatocellular carcinoma patients with opioid-associated constipation
10.12206/j.issn.2097-2024.202309009
- VernacularTitle:消胀通便膏在晚期肝癌患者阿片类药物相关性便秘中的应用研究
- Author:
Yalun HE
1
;
Zhi QI
1
;
Jie CHANG
1
Author Information
1. Department of Integrated Chinese and Western Medicine, b. Department of Nephrology and Neurology, c. Emergency Department, the Third Affiliated Hospital of Naval Medical University, Shanghai 201805, China.
- Publication Type:Medicine&Clinical
- Keywords:
opioid-associated constipation;
advanced hepatocellular carcinoma;
acupoint application;
Chinese herbal plaster
- From:
Journal of Pharmaceutical Practice and Service
2024;42(12):520-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the curative effect ofeliminating flatulence and laxative cream on patients with advanced hepatocellular carcinoma and opioid-associated constipation（OIC）. Methods 120 patients with advanced liver cancer complicated with OIC who were treated at the Third Affiliated Hospital of Naval Medical University from June 2021 to December 2022 were selected as the study subjects. The patients were divided into a control group（lactulose+conventional treatment）and an experimental group（eliminating flatulence and laxative cream + conventional treatment）using a randomized numerical table method. Two groups were compared in terms of defecation, quality of life, and comprehensive post-treatment evaluation（economic cost, number of occurrences of diarrhea, and whether or not there was a change in the dosage of opioids used）. Results After 28 d of intervention, both groups showed better results in relieving OIC（P<0.05）, and the experimental group was significantly better than the control group in terms of the quality of life of patients with advanced hepatocellular carcinoma, the economic cost and the number of diarrhea（P<0.05）. Conclusion In the treatment of OIC in patients with advanced hepatocellular carcinoma, constipation could be relieved by using both topicaleliminating flatulence and laxative cream and oral lactulose solution. Among them, antieliminating flatulence and laxative cream was more acceptable to patients and superior in terms of quality of life and economic cost, which could be a better choice for improving patient satisfaction and safety.
