Progress of Research on Transformation of Chronic Pancreatitis to Cancer
10.3971/j.issn.1000-8578.2024.24.0475
- VernacularTitle:慢性胰腺炎炎-癌转化的研究进展
- Author:
Bangwei HUANG
1
;
Pengyuan WANG
2
,
3
;
Lianghao HU
1
;
Zhaoshen LI
1
Author Information
1. Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200433, China.
2. Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200433, China
3. Department of Gastroenterology, 981 Hospital of Joint Logistic Support Force, Chengde 067000, China.
- Publication Type:SPECIALFEATURE
- Keywords:
Chronic pancreatitis;
Inflammation-cancer transition;
Pancreatic cancer;
Acinar-to-ductal metaplasia;
Pancreatic fibrosis
- From:
Cancer Research on Prevention and Treatment
2024;51(12):989-993
- CountryChina
- Language:Chinese
-
Abstract:
The transformation from inflammation to cancer is a complex pathological process, in which the inflammatory state progresses to the formation of malignant tumors. Chronic pancreatitis (CP) is a progressively inflammatory and fibrosing disease, predominantly featuring acinar cell atrophy owing to the cellular damage and fibrosis of the pancreatic parenchyma. This review centers on elucidating how prolonged exposure to a chronic inflammatory environment prompts adaptive changes in acinar cells, which may ultimately lead to their conversion into cancerous cells. By delving into the pivotal role of acinar-to-ductal metaplasia, this article investigates the multi-stage pathway of CP progression into pancreatic cancer, as well as the underlying molecular regulatory networks. We aim to light on the profound mechanisms of CP's inflammation-driven carcinogenic transformation, and thus provide a scientific foundation for devising innovative preventive strategies and therapeutic interventions targeted at mitigating or halting this lethal conversion process.
