Postpartum depression is a condition that is commonly experienced by postpartum women after childbirth. Determination and detection of factors influencing postpartum depression will help mothers explore evidence-based strategies for early prevention and treatment. A quantitative descriptive survey design was utilized in the study. Data was collected through stratified random sampling. The childbearing mothers in four selected communities of Bontoc, Mountain Province: upland, riverside, AlBaGo, and central Bontoc were the respondents of the study. Data gathered utilized a self-made questionnaire based on journals and research studies about postpartum depression. Results of the study showed that the respondents considered the impact on the extent of factors causing postpartum depression among child bearing mothers. There is a significant difference on the extent of factors influencing postpartum depression among child bearing mothers when grouped according to civil status but no significant difference when grouped according to age, educational attainment and employment status. The respondents ranked the suggested measures to prevent postpartum depression as: 1) psychological, 2) physical and;3) social. Promoting the mental health and well-being of mothers and families through implementation of an evidence-based strategy in the Municipal and Provincial health units can prevent or reduced Postpartum depression. Early interventions on postpartum depression promoted maternal recovery and strong foundations for postpartum mothers. This includes educating mothers, planning health education programs, focusing on early detection, and distributing behavioral change communications through flyers, brochures, and training materials.