Chinese Materia Medica by Regulating Nrf2 Signaling Pathway in Prevention and Treatment of Ulcerative Colitis： A Review
10.13422/j.cnki.syfjx.20250262
- VernacularTitle:中药调控Nrf2信号通路干预溃疡性结肠炎的研究进展
- Author:
Yasheng DENG
1
;
Lanhua XI
2
;
Yanping FAN
1
;
Wenyue LI
1
;
Tianwei LIANG
1
;
Hui HUANG
1
;
Shan LI
3
;
Xian HUANG
3
;
Chun YAO
3
;
Guochu HUANG
3
Author Information
1. Guangxi University of Chinese Medicine，Nanning 530200，China
2. Hainan Traditional Chinese Medicine Hospital，Haikou 570100，China
3. The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530200，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
ulcerative colitis;
nuclear transcription factor E2-related factor 2（Nrf2） signaling pathway;
oxidative stress;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(1):321-330
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis（UC） is a chronic non-specific inflammatory bowel disease characterized by inflammation and ulceration of the colonic mucosa and submucosa， and its complex pathogenesis involves immune abnormality， oxidative stress and other factors. The nuclear transcription factor E2-related factor 2（Nrf2）， encoded by the Nfe212 gene， plays a central role in antioxidant responses. It not only activates various antioxidant response elements such as heme oxygenase-1（HO-1） and quinone oxidoreductase 1（NQO1）， but also enhances the activity of glutathione-S-transferase（GST） and superoxide dismutase 1（SOD1）， effectively eliminating reactive oxygen species（ROS） accumulated in the body， and mitigating oxidative stress-induced damage to intestinal mucosa. In addition， Nrf2 can reduce the release of inflammatory factors and infiltration of immune cells by regulating immune response， cell apoptosis and autophagy pathways， thereby alleviating intestinal inflammation and promoting the repair and regeneration of damaged mucosa. Based on this， this paper reviews the research progress of Chinese materia medica in the prevention and treatment of UC by modulating the Nrf2 signaling pathway. It deeply explores the physiological role of Nrf2， the molecular mechanism of activation， the protective effect in the pathological process of UC， and how active ingredients in Chinese materia medica regulate the Nrf2 signaling pathway through multiple pathways to exert their potential mechanisms. These studies have revealed in depth that Chinese materia medica can effectively combat oxidative stress by regulating the Nrf2 signaling pathway. It can also play a role in anti-inflammatory， promoting autophagy， inhibiting apoptosis， protecting the intestinal mucosal barrier， and promoting intestinal mucosal repair， providing new ideas and methods for the multi-faceted treatment of UC.
