Research Progress on Pathogenesis of Osteoporosis and Intervention of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20241136
- VernacularTitle:骨质疏松症的发病机制及中医药治疗研究进展
- Author:
Xiaoyun ZHANG
1
;
Hao ZENG
2
;
Zhengpeng LI
2
;
Yueping CHEN
1
Author Information
1. Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine， Nanning 530011， China
2. Graduate School， Guangxi University of Chinese Medicine， Nanning 530000， China
- Publication Type:Journal Article
- Keywords:
osteoporosis;
pathogenesis;
osteoblasts;
osteoclasts;
bone metabolism;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(1):311-320
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis （OP） is a metabolic disorder characterized by microstructural deterioration of bone and increased bone fragility due to reduced bone mass， which can cause the development of bone-related diseases. This condition imposes significant economic and psychological burdens on patients. While modern medicine has extensively researched the pathogenesis of OP， it remains incompletely understood. Current clinical management primarily relies on anti-resorptive drugs and synthetic metabolic agents. However， long-term use of some medications may yield suboptimal therapeutic outcomes and lead to severe adverse reactions. Given the necessity for prolonged or lifelong treatment for OP， there is a critical need to identify highly effective， safe， and cost-effective pharmaceutical interventions. In light of evolving disease management paradigms and recent advancements in OP research， traditional Chinese medicine has demonstrated emerging advantages in addressing this condition. Through literature review， this study delves into the pathogenesis of OP from five perspectives： hormonal dysregulation， autophagy， ferroptosis， oxidative stress， and intestinal flora alteration. Furthermore， it summarizes the therapeutic efficacy and specific mechanisms of traditional Chinese medicine monomers and compound formulas against OP through regulating hormone levels， interfering with autophagy， inhibiting ferroptosis， counteract oxidative stress，and maintain intestinal flora balance. These multifaceted insights are expected to provide theoretical reference and guide future clinical traditional Chinese medicine approaches for preventing and managing OP.
