Role of Intestinal Microbiota in "Correspondence Between Prescription and Syndrome"
10.13422/j.cnki.syfjx.20241138
- VernacularTitle:刍议肠道菌群在“方-证相应”中的作用
- Author:
Junxi SHEN
1
;
Leyao FANG
1
;
Zhoujin TAN
1
Author Information
1. Hunan University of Chinese Medicine，Changsha 410208，China
- Publication Type:Journal Article
- Keywords:
syndrome;
prescription;
intestinal microbiota;
correspondence between prescription and syndrome;
correspondence between intestinal microbiota and syndrome;
correspondence between intestinal microbiota and prescription;
correspondence among intestinal microbiota， syndrome， and prescription
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(1):267-275
- CountryChina
- Language:Chinese
-
Abstract:
"Correspondence between prescription and syndrome" is the foundation of the objectification of traditional Chinese medicine diagnosis and treatment， and the objectification of traditional Chinese medicine diagnosis is the key to the modernization of traditional Chinese medicine. Combining modern theories and technological means to explore objective indicators or biomarkers of "correspondence between prescription and syndrome" can help clarify quantitative indicators of syndromes. There is a characteristic microbial population in the intestine that is related to syndromes and prescription efficacy. Intestinal microbiota plays an important indicative and discriminative role in determining the formation and evolution of disease patterns and is also an important characterization and pathway of the therapeutic effect of prescriptions. Therefore， intestinal microbiota can serve as an important biological indicator for the objectification of "correspondence between prescription and syndrome"， and the research content related to "intestinal microbiota-syndrome" and "intestinal microbiota-prescription" is relatively mature. On this basis， the team proposed a research approach and method of "correspondence among intestinal microbiota， syndrome， and prescription"， exploring the biological mechanism of "correspondence between prescription and syndrome" from the perspective of intestinal microbiota. A complete analysis of the "intestinal microbiota-syndrome-prescription" data content of six traditional Chinese medicine diarrhea syndromes was conducted， and the results of intestinal dominant and characteristic microbiota for different syndromes of diarrhea and corresponding formula interventions were obtained. The correlation of key intestinal microbiota and metabolites with the interaction between different syndromes and formula interventions was studied， and the microbiological mechanism of "treating the same disease with different methods" for diarrhea was explored. The research ideas and results provide the possibility for the establishment and application of the theory of "correspondence among intestinal microbiota， syndrome， and prescription" and also provide a research paradigm for other diseases in traditional Chinese medicine. "Correspondence among intestinal microbiota， syndrome， and prescription" is conducive to revealing the micro-mechanisms of the formation and evolution of traditional Chinese medicine syndromes and the efficacy of prescriptions. It establishes an objective diagnosis and treatment system for traditional Chinese medicine syndromes based on intestinal microbiota， providing new methods and ideas for the objective diagnosis and treatment of traditional Chinese medicine syndromes and promoting the modernization and internationalization of traditional Chinese medicine.
