Current Situation， Problems and Countermeasures of Experimental Research on Traditional Chinese Medicine Regulating PI3K/Akt Signaling Pathway in Rats with Polycystic Ovary Syndrome
10.13422/j.cnki.syfjx.20241263
- VernacularTitle:中药调控PI3K/Akt信号通路干预多囊卵巢综合征大鼠实验研究的现状、问题及对策
- Author:
Pengxuan YAN
1
;
Yiqing LIU
1
;
Nanxing XIAN
1
;
Linjing PENG
1
;
Kun LI
1
;
Jingchun ZHANG
2
;
Yukun ZHAO
3
Author Information
1. China Academy of Chinese Medical Sciences，Beijing 100700，China
2. Xiyuan Hospital， China Academy of Chinese Medical Sciences，Beijing 100091，China
3. Institute of Basic Theory for Chinese Medicine，China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine（TCM）;
polycystic ovary syndrome（PCOS）;
phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt） signaling pathway;
current status and problems;
animal model;
kidney deficiency type;
protein
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(1):259-266
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome（PCOS） and its resulting infertility is one of the common diseases of gynecology and reproductive endocrinology. The phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt） signaling pathway is relatively well-studied in the development of intervention in PCOS， and the experiments on PCOS in rats conducted by traditional Chinese medicine through this signaling pathway is also the main direction of mechanistic research. In this paper， 20 articles published in academic journals in the past 5 years were selected through the corresponding criteria， and the objective situation and existing problems of the selected research projects were analyzed from five aspects， namely， baseline data， modeling and treatment， grouping， evaluative indexes， and pharmacodynamic indexes. It is found that there were different degrees of problems in each research project， such as the observation indicators of modeling， criteria for judging the success of the model， the treatment period， the calculation of dosage of prescription/active ingredients and specific dosage were not clearly defined， which could easily lead the bias of the results or reduce the validity of experimental data. Based on this， the list of PCOS rat experimental research operations was formed， involving five categories of experimental rats， model construction， study implementation， outcome measures and analysis and report with a total of 21 operation lists， with a view to provide a reference for the subsequent PCOS experiments related to scientific research and helping to form high-quality results.
