Theoretical Exploration of Diabetic Retinopathy Guided by Luobing Theory
10.13422/j.cnki.syfjx.20241266
- VernacularTitle:络病理论指导糖尿病性视网膜病变理论探析
- Author:
Liping CHANG
1
;
Jing MA
2
;
Kun MA
2
;
Zhenhua JIA
3
;
Cong WEI
1
Author Information
1. National Key Laboratory for Innovation and Transformation of Luobing Theory，Shijiazhuang 050035，China
2. Key Laboratory of National Administration of Traditional Chinese Medicine（Cardiovascular and Cerebrovascular Luobing），Hebei Yiling Institute of Medicines，Shijiazhuang 050035，China
3. Hebei Yiling Hospital，Shijiazhuang 050091，China
- Publication Type:Journal Article
- Keywords:
diabetes mellitus;
diabetic retinopathy;
Luobing theory;
venation theory;
tertiary collaterals-microvascular;
Tongluo Mingmu capsules
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(1):253-258
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy（DR）， as one of the most common and serious microvascular complications of diabetes mellitus， seriously threatens human health， and belongs to "Xiaoke eye diseases" in traditional Chinese medicine（TCM）， which has been richly experienced by medical practitioners through the ages， but is mostly recorded in a piecemeal manner and has not been systematically researched. This disease is featured by long course and repeated attack， and is refractory， which belongs to the research category of "persistent illness entering collaterals". Systematic establishment of TCM collateral disease theory for guiding prevention and treatment of DR has important clinical value. On the basis of close correlation between tertiary collaterals at the terminal of collaterals and capillaries and microcirculation， the concept of "tertiary collaterals-microvascular" is proposed. It is pointed out that DR falls within the scope of "tertiary collaterals-microvascular" diseases， and presents four types of micro-pathological characteristics， including stasis， insufficiency， growth and bleeding of tertiary collaterals. It is concluded that "deficiency of both Qi and Yin" is the basic pathogenesis of DR， and "blood stasis and collateral obstruction" is the important pathogenesis and key factor. Thus， the treatment method of "dispersing blood stasis， dredging collateral， tonifying Qi and Yin， stopping hemorrhage and improving eyesight" is determined， and the formula of Tongluo Mingmu capsules is developed. The article tightly focuses on the pathological changes such as stasis， growth， insufficiency and bleeding of collaterals， addresses both symptoms and root causes， and plays a synergistic role of both dispersing stasis and stopping bleeding. In this way， it can realize the purpose of tonifying Qi and Yin to replenish the essence， dispersing stasis and dredging collaterals to meet the requirement， as well as stopping hemorrhage and improving eyesight to deal with changes. Fundamental researches demonstrate that Tongluo Mingmu capsules has synergy effects of protecting both retinal capillaries and retinal cells. Phase-Ⅲ clinical trial of new drug has proven definite clinical efficacy and good safety， which provides a new drug choice for enhancing clinical effect of DR， and further supports the scientific value of Luobing theory in preventing and treating DR and other clinically significant diseases.
