Advances of Interleukin-6 in Pulmonary Hypertension
10.13748/j.cnki.issn1007-7693.20230492
- VernacularTitle:IL-6在肺动脉高压中的研究进展
- Author:
Tingting CHEN
1
;
Jin YANG
2
;
Dianxiang LU
2
Author Information
1. Medical College of Qinghai University, Xining 810001, China
2. Affiliated Hospital of Chengdu University, Chengdu 610086, China
- Publication Type:Journal Article
- Keywords:
interleukin-6；pulmonary hypertension；pulmonary arterial smooth muscle cell；pulmonary vascular remodeling；effect and mechanism
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(10):1438-1446
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-6(IL-6) is a pleiotropic cytokine, which plays an important role in the inflammatory response. There is increasing evidence that IL-6 also plays a very important role in the development of pulmonary hypertension, as evidenced by the fact that circulating levels of IL-6 are significantly elevated in pulmonary hypertension patients and animal models, that overexpression of IL-6 in mice can induce severe pulmonary hypertension, and that treatment targeting IL-6 can improve pulmonary hypertension. This paper reviews the research progress on the role of IL-6 in pulmonary hypertension and its mechanism at the molecular level, and introduce the current candidate regimens targeting IL-6 for the treatment of pulmonary hypertension, in order to provide a reference for clinical drug research and development for pulmonary hypertension.
