Research Progress in Closed-loop Insulin Delivery Systems
10.13748/j.cnki.issn1007-7693.20232470
- VernacularTitle:闭环胰岛素输送系统的研究进展
- Author:
Xiangqian WEI
1
;
Xiuwen ZHANG
1
;
Yanfang WANG
1
;
Xinwei WEI
1
;
Juan ZHANG
1
;
Kangfan JI
1
;
Shiming ZHANG
2
;
Zhen GU
3
;
Jinqiang WANG
4
Author Information
1. Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2. Department of Electrical and Electronic Engineering the University of Hong Kong, Hong Kong 999077, China
3. Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China；Jinhua Institute of Zhejiang University, Jinhua 321299, China；National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China；Zhejiang University Medical Center, Liangzhu Laboratory, Hangzhou 311121, China；MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China；Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
4. Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China；Jinhua Institute of Zhejiang University, Jinhua 321299, China；National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China；Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310009, China
- Publication Type:Journal Article
- Keywords:
drug delivery；closed-loop therapies；insulin delivery system；type 1 diabetes；glucose responsive
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(10):1303-1312
- CountryChina
- Language:Chinese
-
Abstract:
Individuals with type 1 diabetes or advanced type 2 diabetes suffer insufficient insulin secretion, leading to symptoms of hyperglycemia. To maintain the normal blood glucose levels, those people with diabetes must administer insulin multiple times a day. However, insulin requirements are influenced by several factors such as diet, exercise, and illness, combined with the narrow therapeutic index, making accurate insulin dosage challenging. Excessive insulin administration can even pose life-threatening risks. In addition, frequent daily insulin injections place considerable physiological and psychological burdens on patients. To tackle these challenges, researchers have embarked on the development of closed-loop insulin delivery systems. These systems adjust insulin dosages in real-time changes based on the patient’s blood glucose levels, therefore enhancing both the safety and effectiveness of insulin therapy. This review categorizes closed-loop insulin delivery systems into two types: electronic-based and material-based systems, based on their compositional attributes. The exploration of both types covers their components, developmental history, clinical applications, current pros and cons, and future directions. The relative strengths and limitations of these two categories of closed-loop insulin delivery systems are also compared and discussed.
