Analysis of Influencing Factors and Security on the Plasma Concentration of Anti-tuberculosis Drugs in Children
10.13748/j.cnki.issn1007-7693.20232515
- VernacularTitle:儿童结核患者抗结核药物血药浓度影响因素及其安全性分析
- Author:
Junjie CHENG
1
;
Jinmeng LI
1
;
Ruoying ZHANG
1
;
Xinjun CAI
1
Author Information
1. Department of Pharmacy, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou 310003, China
- Publication Type:Journal Article
- Keywords:
children； anti-tuberculosis drugs；therapeutic drug monitoring；security analysis
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(9):1247-1254
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To monitor plasma concentration of anti-tuberculosis drugs in children, and explore the influencing factors and safety of anti-tuberculosis drugs, and promote the rational use of drugs.
METHODS
The plasma drug concentration monitoring results of isoniazid, rifampicin, pyrazinamide and ethambutol, the adverse drug reactions and the changes of various parameters before and after treatment in 40 children with tuberculosis were analyzed retrospectively in Zhejiang Hospital of Integrated Tradtional Chinese and Western Medicine.
RESULTS
The compliance rates of plasma drug concentration of isoniazid, rifampicin, pyrazinamide and ethambutol in chlidren with tuberculosis were 48.15%, 34.88%, 73.81%, 18.52%, respectively. Isoniazid(P=0.0250), rifampicin(P=0.0212) concentrations were positively correlated with daily dose. Age was also one of the factors affecting the concentrations of isoniazid(P=0.0430) and rifampicin(P=0.0057). Serum albumin(P=0.0475) and sex(P=0.0087) were correlated with rifampicin and pyrazinamide, respectively. Abnormal liver function(5/40, 12.50%) and rash(4/40, 10%) were the most common adverse drug reaction. Aspartate aminotransferase(AST), alanine aminotransferase(ALT) and uric acid levels increased after treatment with anti-tuberculosis drugs.
CONCLUSION
The plasma drug concentrations of isoniazid, rifampicin and ethambutol in children are low. The anti-tuberculosis drugs maybe related to the increase of AST, ALT and uric acid. Therefore, monitoring of serum drug concentration, renal fuction and liver function during anti-tuberculosis treatment is helpful to improve drug safety and implement individualized treatment.
