The clinical significance of P300 and EMT⁃related proteins in synovial sarcoma
- Author:
Hao Chen
1
,
2
,
3
;
Zhen Zhang
4
,
5
;
Ning Wang
1
,
2
,
3
;
Shuangshuang Dong
1
,
2
,
3
;
Xiaojuan Lian
6
;
Weihua Liang
1
,
2
,
3
;
Jinfang Jiang
1
,
2
,
3
;
Lijuan Pang
1
,
2
,
3
;
Yan Qi
1
,
2
,
3
,
7
,
8
Author Information
- Publication Type:Journal Article
- Keywords: synovial sarcoma; P300; SYT-SSX; epithelial mesenchymal transition; immunohistochemistry
- From: Acta Universitatis Medicinalis Anhui 2022;57(2):315-319, 324
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the role and its clinical significance of P300 in biphasic differentiation and epithelial mesenchymal transition ( EMT) process in synovial sarcoma (SS) by detecting the expression of histone
acetyltransferase P300 and EMT related molecules.
Methods : 40 cases of SS paraffin embedded tissue samples were collected , and the SYT⁃SSX fusion gene subtype was detected by RT⁃PCR. Immunohistochemistry was used to detect the expression of P300 and EMT⁃related molecules.
Results
Conclusion :P300 may be involved in the biphasic differentiation and the EMT process of SS , suggesting that P300 plays a certain role in SS invasion and migration. - Full text:2024121915211938261滑膜肉瘤中P300与EMT相关蛋白的表达及临床意义_陈浩.pdf
