Progress in the Application of Non-cell-based Permeation Model in the Study of the Permeability of BSC Class Ⅱ Drugs
10.13748/j.cnki.issn1007-7693.20230310
- VernacularTitle:非细胞渗透模型在BSCⅡ类药物渗透性研究中的应用进展
- Author:
Wenna WU
1
;
Li DING
1
;
Zhongliang FENG
1
;
Xiaoming HE
1
;
Chaoxing HE
1
;
Yu FANG
1
Author Information
1. Department of Pharmaceutics, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
- Publication Type:Journal Article
- Keywords:
permeability；BSC class Ⅱ drugs；non-cell-based permeation model； biomimetic barrier；hollow fiber membrane
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(8):1135-1141
- CountryChina
- Language:Chinese
-
Abstract:
Permeability is one of the determinants of intestinal absorption and oral bioavailability. The non-cell-based permeation model is a kind of in vitro permeability measurement tool, which has the advantages of high efficiency, low cost, stable property, easy to use and customizable. According to the barrier type, non-cell-based permeation model can be divided into biomimetic barriers containing (phosphate) lipids and non-biomimetic barriers without lipids. Biomimetic permeation models include parallel artificial membrane permeability assay, vesicle-based permeation assay and PermeaPad®. Non biomimetic permeation models include Hollow fiber membrane models based on polyether sulfone materials. In foreign countries, the application of these four barriers for different purposes is gradually becoming a hot spot in drug absorption research. However, in China, there are only more applied studies on PMAPM and few published applied studies on the other three barriers. In order to meet the development needs of insoluble drug formulations, the author summarized the permeability devices and permeability calculation methods, searched the application of non-cell-based permeation model in the permeability of BSCⅡ drugs in recent years, and summarized the characteristic applications of three Biomimetic permeation models and hollow fiber membranes.
