Association study of vitamin D receptor gene polymorphisms and clinical outcome of acute pancreatisis
10.19405/j.cnki.issn1000-1492.2022.02.022
- Author:
Yu Liu
1
;
Yuhan Yan
1
;
Fang Huang
1
;
Lei Guo
1
;
Yangxi Chen
1
;
Chen Yang
1
;
Xinghu Zhang
1
;
Wenhui Wan
1
Author Information
1. The First Dept of Cadre Ward , General Hospital of Eastern Theater Command ,PLA , Nanjing 21000
- Publication Type:Journal Article
- Keywords:
vitamin D receptor;
polymorphism;
acute pancreatisis;
clinical outcome
- From:
Acta Universitatis Medicinalis Anhui
2022;57(2):279-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the relationship between vitamin D receptor (VDR) gene polymorphisms and the clinical prognosis of acute pancreatitis (AP) , and to provide a genetic basis for early identification of critically
ill patients.
Methods : A total of fourteen single nucleotide polymorphisms (SNPs) on the VDR gene were detected in 508 AP patients by using improved ligase detection reaction (imLDR) technology. Unconditional Logistic regression analysis was used to explore the association of VDR gene polymorphisms with outcome ( sepsis/severe AP/death) of AP patients after adjusting for age , sex , body mass index(BMI) , smoking and drinking status and APACHE II score under different genetic models.
Results : Rs12721375 GA/AA genotype had a lower risk of sepsis than GG (P = 0. 02) and the A allele had a lower risk of sepsis than G (P = 0. 009) . Rs2853559 GA and GA/AA had higher risks of sepsis than GG (P = 0. 022 and 0. 026 respectively) . Rs11168287 AA had a higher risk of severe AP than GG and GG/GA (P = 0. 030 and 0. 022 respectively) . Rs2853559 AA genotype had a higher risk of severe AP than GG and GG/GA ( P = 0. 022 and 0. 021 respectively) . The risk of death of rs11168283 CT/TT genotype was lower than that of CC (P = 0. 046) .
Conclusion :VDR gene polymorphisms are related to the clinical outcome of AP patients in Chinese Han population. VDR gene is involved in the progression of AP.
- Full text:2024121911064873899维生素D受体基因多态性与急性胰腺炎临床转归的关联研究_刘瑜.pdf
