Expression of TRPV 1 and OTR in eutopic/ectopic endometrium and their correlation with dysmenorrhea in adenomyosis
10.19405/j.cnki.issn1000-1492.2022.02.021
- Author:
Guo Chen
1
,
2
;
Yuting Zhu
1
;
Hui Yao
1
;
Weiyu Zhang
1
;
Shuguang Zhou
1
,
2
;
Xiaomin Jiang
1
,
2
Author Information
1. Dept of Gynecology, Maternal and Child Health HospitalAfiliated to Anhui Medical University, Hefei 230001
2. Dept of Gynecology, Anhui Province Maternity and Child Health Hospital , Hefei 230032
- Publication Type:Journal Article
- Keywords:
adenomyosis;
transient receptor potential vanilloid subtype 1;
oxytocin receptor;
dysmenorrhea
- From:
Acta Universitatis Medicinalis Anhui
2022;57(2):273-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To investigate the roles of transient receptor potentia1 vanilloid 1 ( TRPV 1) and oxytocin
receptor ( OTR) in the mechanism of dysmenorrhea in adenomyosis.
Methods :The ectopic endometrium ( EC) and the homologous eutopic endometrium (EU) were selected from 60 patients with adenomyosis surgery , and the control endometrium (CE) of patients without endometriosis was used as control. Streptavidin⁃Peroxidase immunosion of TRPV 1 and OTR was detected by Western blot. The degree of dysmenorrhea was scored by visual analogue scale/score (VAS) , and its correlation with the TRPV 1 and OTR was analyzed.
Results :The expression of TRPV 1 and OTR in EC was higher than that in EU and CE (P < 0. 05) , but there was no statistically significant difference between EU and CE. In EC , the expression of TRPV 1 and OTR in the severe dysmenorrhea group was higher than that in the mild and moderate groups (P < 0. 05) , but there was no statistically significant difference between the mild dysmenorrhea group and the moderate group. The expression of TRPV 1 and OTR was positively correlated with the severity of dysmenorrhea ( rs = 0. 280 , P < 0. 05 ; rs = 0. 318 , P < 0. 05) ; the expression of TRPV 1 and OTR was positively correlated ( rs = 0. 287 , P < 0. 05) .
Conclusion :TRPV 1 and OTR may play a synergistic role in the pathogenesis of dysmenorrhea in patients with adenomyosis , which are important predictors of dysmenorrhea severity and potential therapeutic targets.
- Full text:202412191102239973子宫腺肌病在位_异位内膜T...R的表达与痛经的相关性研究_陈果.pdf
