Pharmacodynamics Study of Wujiashen Gejiejing on Model Rats with Deficiency of Lung Qi
10.13748/j.cnki.issn1007-7693.20220045
- VernacularTitle:五加参蛤蚧精对肺气虚模型大鼠药效学研究
- Author:
Bin QIAO
1
;
Zhengyi ZHANG
2
;
Yulian SHI
2
;
Chuanjia ZHAI
2
;
Xuejiao LI
2
;
Xiaoyan GAO
2
Author Information
1. Sunflower Pharmaceutical Group Co., Ltd., Herbin 150078, China
2. Beijing University of Chinese Medicine, Beijing 102401, China
- Publication Type:Journal Article
- Keywords:
Wujiashen Gejiejing ； deficiency of lung qi；pharmacodynamics
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(7):906-910
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To evaluate the pharmacodynamics of Wujiashen Gejiejing on rats with deficiency of lung qi.
METHODS
The rat model of deficiency of lung qi was established by sawdust fumigation. By comparing the general activity state, blood acid-alkali indexes, biochemical indexes related to chronic bronchitis and airway histological characteristics of rats in each group, the pharmacodynamics of Wujiashen Gejiejing on rats with deficiency of lung qi was evaluated.
RESULTS
Compared with model group, after the Wujiashen Gejiejing intervention, the body weight of the rats significantly increased; the levels of p(O2) and SaO2 in blood were significantly increased(P<0.001), p(CO2) was significantly decreased(P<0.05), and pH had a tendency to increase; the levels of endothelin(ET) and IL-1β in serum were significantly decreased(P<0.01 or P<0.05), and the levels of TNF-α in serum had a decreasing trend. The damaged lung structures were significantly improved.
CONCLUSION
Wujiashen Gejiejing can significantly improve the activity state and improve hypoxemia and hypercapnia of lung qi deficiency syndrome, improve the damaged lung structure and the function of lung ventilation, and has obvious anti-inflammatory effect. Its mechanism may be related to regulating the expression of inflammatory cytokines IL-1β, TNF-α and ET.
