Analysis of Severe Adverse Drug Reactions and Drug Interactions in 360 Cases
10.13748/j.cnki.issn1007-7693.20232045
- VernacularTitle:360例严重药品不良反应和药物相互作用的分析
- Author:
Yanhua LIN
1
;
Xiaoqun LYU
2
;
Weifang REN
2
;
Yujuan LIU
2
;
Kang JIANG
2
;
Huaqiao JIANG
2
Author Information
1. Jinshan Hospital, Fudan University Department of Nursing
2. Jinshan Hospital, Fudan University Department of Pharmacy, Shanghai 201508, China
- Publication Type:Journal Article
- Keywords:
real-world ； serious adverse drug reaction ；drug-drug interactions； elderly patients；rational use of drugs
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(5):696-701
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To analyze and evaluate serious adverse drug reaction(SADR) and drug-drug interactions(DDIs) in the real-world, so as to obtain the clinical evidence of DDIs-related SADR, and to provide a reference for rational clinical use.
METHODS
The SADR reports reported to the National Adverse Drug Reaction Monitoring Center from January 2011 to December 2020 were collected, and Lexi-Interaction® software in UpToDate was used to analyze ≥2 drugs in SADR to evaluate whether there were potential DDIs. And the possible adverse drug reactions caused by DDIs were statistically analyzed.
RESULTS
Among the 360 cases of SADR, males were slightly more than females(50.83% vs 49.17%), the mean age was (65.27±14.71) years old, and 56.39% were ≥65 years old. Cardiovascular agents were the most common implicated pharmacological group, and the gastrointestinal system was the most frequently affected system, and aspirin was the most frequently reported drug. Among 150 cases of SADR with at least two suspected drugs, 64 cases had potential DDIs, while 42 cases had clinically significant DDIs, of which only 16 and 2 cases of SADR were caused by actual DDIs in category D and X, respectively. The majority of reports(71.43%) were caused by additive pharmacodynamic interactions. Aspirin was the most common drug in both potential DDIs and actual DDIs, while aspirin and clopidogrel was the most commonly involved drug pair in actual DDIs, with gastrointestinal bleeding being the most common SADR.
CONCLUSION
Attention should be paid to the influence of drug interactions on SADR, and prescription should be optimized, especially in the elderly population. According to the results of potential DDIs, therapeutic drugs should be rationally selected. Meanwhile, monitoring of cardiovascular drugs and key populations should be strengthened to ensure drug safety.
