Optimization of the Forming Process of Mingmu Yijing Pills Based on AHP-CRITIC Mixed Weighting Method
10.13748/j.cnki.issn1007-7693.20224045
- VernacularTitle:基于AHP-CRITIC赋权法优化明目益睛丸成型工艺
- Author:
Chunhong YANG
1
;
Shu LI
2
;
Qi ZHAO
1
;
Qian SHI
1
;
Yanxiong GAN
1
;
Xianrong LAI
1
;
Rui LI
2
Author Information
1. Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2. Meishan Hospital of Traditional Chinese Medicine, Meishan 620000, China
- Publication Type:Journal Article
- Keywords:
Mingmu Yijing pills ； forming process ； AHP ；CRITIC； AHP-CRITIC mixed weighting method ； Box-Behnken response surface method
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(5):672-677
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To clarify the weight index and optimize the technology of compound Mingmu Yijing pills.
METHODS
Water content, dissolution time limit and bolus-forming pass rate were included as evaluation indexes. The analytic hierarchy process(AHP) and the criterion importance through inter-criteria correlation(CRITIC) method based on the objectivity of indicators were adopted, AHP-CRITIC mixed weighting method. In this way, the relative coefficients of each index were calculated for weight distribution and comprehensive score, and the molding process was optimized and verified by Box-Behnken response surface test.
RESULTS
Compared with the single weighting method, the AHP-CRITIC mixed weighting method was more reasonable and stable. This method finally optimized the forming process conditions of Mingmu Yijing pills as follows: adding water amount of 0.8 times, the damp mass infiltration for 0.5 h, drying temperature of 60 ℃, drying time of 8 h. The mean comprehensive score of validation experiment was 88.21, RSD was 0.29%.
CONCLUSION
AHP-CRITIC method scientifically determines the weight of multiple indicators, and the verification test confirms that the optimized molding process is stable and feasible, which can be used in practical large-scale production.
