Research Progress of Traditional Chinese Medicine Intervention on Intervertebral Disc Degeneration Based on Oxidative Stress
10.13748/j.cnki.issn1007-7693.20223348
- VernacularTitle:基于氧化应激的中医药干预椎间盘退变的研究进展
- Author:
Zhenghan YANG
1
;
Jirong ZHAO
1
;
Junfei MA
1
;
Qianwen CHEN
1
;
Wen CHEN
2
;
Ning ZHAO
2
Author Information
1. Gansu University of Chinese Medicine, Lanzhou 730000, China
2. Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
- Publication Type:Journal Article
- Keywords:
oxidative stress； intervertebral disc degeneration ； reactive oxygen species ； traditional Chinese medicine
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(1):138-144
- CountryChina
- Language:Chinese
-
Abstract:
Intervertebral disc degeneration(IDD) is the pathological basis of spinal diseases. With the development and change of working and living style, IDD gradually presents the trend of younger in recent years. The effective prevention and treatment of IDD has become a hotspot in clinical research. Recent studies have shown that oxidative stress plays an important role in IDD. The disruption of reactive oxygen species balance in cells or the body leads to changes in extracellular matrix and intervertebral disc cell phenotype, which induces oxidative stress of intervertebral disc and leads to IDD. Oxidative stress can affect the development of IDD through apoptosis, autophagy, senescence and extracellular matrix of intervertebral disc. Currently, opioids and drugs for promoting blood circulation and pain relief are commonly used in clinical treatment of IDD, which can alleviate some symptoms to a certain extent, but is easy to induce gastrointestinal and other adverse reactions. Meanwhile, due to the long treatment cycle and poor patient compliance to a certain extent, which brings great difficulties to the treatment. At the same time, traditional Chinese medicine plays an important role in the treatment of IDD due to its advantages of low cost and fewer adverse reactions. With the in-depth research of modern technologies such as molecular biology and network pharmacology, it has been found that traditional Chinese medicine can intervene in the expression of oxidative stress-related functions, namely, slowing down apoptosis, autophagy and degradation of extracellular matrix, etc, to play a role in the treatment of IDD. In this paper, the role of oxidative stress in IDD and the research results on the intervention of traditional Chinese medicine in oxidative stress will be expounded, in order to provide reference for the prevention and treatment of IDD by traditional Chinese medicine.
