Meta-analysis of Association Between HLA-B Gene Polymorphism and Antiepileptic Lamotrigine-induced Cutaneous Adverse Drug Reactions
10.13748/j.cnki.issn1007-7693.20223831
- VernacularTitle:HLA-B基因多态性与抗癫痫药拉莫三嗪致皮肤不良反应关系的meta分析
- Author:
Tangxue LI
1
;
Huiting LI
2
;
Yan WU
2
;
Dianlei WANG
1
;
Tianlu SHI
3
Author Information
1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
2. Department of Pharmacy, the First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, Hefei 230001, China
3. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China；Department of Pharmacy, the First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, Hefei 230001, China
- Publication Type:Journal Article
- Keywords:
HLA-B ； lamotrigine； cutaneous adverse drug reactions ； epilepsy ； meta-analysis
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(1):126-132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To systematically evaluate the association between human leukocyte antigen B(HLA-B) gene polymorphisms and lamotrigine-induced cutaneous adverse drug reactions(LTG-cADRs).
METHODS
CNKI, Wanfang Data, VIP, PubMed, Web of Science, Science Direct were comprehensively searched from the inception to July 15, 2022. The software RevMan 5.4 was used for the meta-analysis.
RESULTS
A total of 16 case-control studies were included, 331 patients with LTG-cADRs epilepsy, including 94 lamotrigine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis(LTG-SJS/TEN) patients, 232 lamotrigine-maculopapule(LTG-MPE) patients and 5 lamotrigine- drug rash with eosinophilia and systemic symptoms(LTG-DRESS) patients; 612 lamotrigine-tolerant patients. Meta-analysis results showed that the HLA-B*1502 allele was significantly associated with LTG-SJS/TEN(OR=3.03, 95%CI: 1.70−5.39, P=0.000 2). The HLA-B*1502, HLA-B*5801, HLA-B*1302 alleles were not significantly associated with LTG-MPE.
CONCLUSION
HLA-B*1502 allele is associated with LTG-SJS/TEN, which may be a risk gene for LTG-SJS/TEN. HLA-B*1502, HLA-B*5801, HLA-B*1302 are not associated with LTG-MPE.
