Role of TRPV1 in Cardiovascular Disease and the Related Progress of Traditional Chinese Medicine Research

Hongying Lyu; Mingshuang Hou; Guanjun Jia; Yushun Kou; Mengyao LI; Yongxiang LI; Jing XU; Qianqian Chen; Zhengjie Teng; Lin YI

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Role of TRPV1 in Cardiovascular Disease and the Related Progress of Traditional Chinese Medicine Research

VernacularTitle:TRPV1在心血管疾病中的作用及相关中医药研究进展
Author: Hongying LYU ¹ ; Mingshuang HOU ¹ ; Guanjun JIA ¹ ; Yushun KOU ¹ ; Mengyao LI ¹ ; Yongxiang LI ¹ ; Jing XU ¹ ; Qianqian CHEN ¹ ; Zhengjie TENG ² ; Lin YI ¹
Author Information

1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China；Gansu Provincial Key Laboratory of TCM Prevention and Treatment of Chronic Diseases, Lanzhou 730000, China
2. Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
Publication Type:Journal Article
Keywords: transient receptor potential vanilloid-1 ； capsaicin receptor ； cardiovascular diseases ； traditional chinese medicine
From: Chinese Journal of Modern Applied Pharmacy 2024;41(4):556-566
CountryChina
Language:Chinese
Abstract: Transient receptor potential vanilloid-1(TRPV1) channel is a non-selective ligand-gated cationic channel with multiple activation mechanisms in the transient receptor potential subfamily. In recent years, a large number of studies have found that TRPV1 plays an important role in the field of cardiovascular diseases such as hypertension and atherosclerosis. With the in-depth study of traditional Chinese medicine, it has been found that Chinese medicine monomers and their active components can activate or inhibit TRPV1 channels, which has certain potential in the study of cardiovascular diseases. In this paper, the role of TRPV1 channel in cardiovascular diseases and the research progress of traditional Chinese medicine prevention and treatment of cardiovascular diseases based on TRPV1 channel are reviewed, in order to provide new ideas for prevention and treatment of cardiovascular system diseases.