Pharmacodynamic Comparative of the Novel Huoxue Plaster and the Original Powder in Treating Chronic Soft Tissue Injury
10.13748/j.cnki.issn1007-7693.20231925
- VernacularTitle:新型活血贴膏与原散剂治疗慢性软组织损伤的药效学比较研究
- Author:
Fanghao ZHENG
1
;
Tingting ZHAO
2
;
Huana FAN
3
;
Yanfen CHEN
3
Author Information
1. Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China；The Eighth School of Clinical Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, China
2. The Eighth School of Clinical Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, China
3. School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
- Publication Type:Journal Article
- Keywords:
Huoxue plaster ； Huoxue powder ； anti-inflammatory effect ； analgesia ； soft tissue injury
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(4):496-503
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To compare the efficacy of the novel Huoxue plaster and the original powder in the treatment of chronic soft tissue injury, and to provide experimental basis for the development and clinical application of hospital preparations.
METHODS
According to the different drug administration, mice were assigned to the blank group, the matrix group, the positive control group(voltaren group), the original powder raw product group, the original powder product group and the novel plaster group respectively. The writhing inhibition rate, licking time, analgesic rate and pain threshold were measured by the writhing test, formaldehyde pain test, electrical stimulation test and hot plate test. The purpose of these was to assess disparities in the drugs for analgesic purposes. The mice ear swelling test and capillary permeability test were used to determine the swelling degree, swelling inhibition rate and exudation inhibition rate to compare the differences in anti-inflammatory effects. A rat model of chronic soft tissue injury was established. The changes of calf circumference, soft tissue injury appearance score, hemorheology and histopathological observation and inflammatory factor content were compared before and after the reform of prescription and dosage form.
RESULTS
The novel Huoxue plaster had a significant inhibitory effect on the inflammatory pain induced by acetic acid and formaldehyde in mice, and there was no significant difference compared with the original powder. The analgesic effect of 60 min after administration was better than that of 90 min and 120 min after administration, and there was no significant difference compared with the original powder. The novel Huoxue plaster and the original powder had no significant effect on hot plate pain threshold. The novel Huoxue plaster had a significant anti-inflammatory effect, which could reduce the degree of ear swelling induced by xylene and reduce the inflammatory exudation of capillaries induced by acetic acid, and there was no significant difference compared with the original powder. The novel Huoxue plaster could significantly reduce the circumference and injury symptom index of the swollen leg in rats with chronic soft tissue injury, improve blood circulation and histomorphology, and significantly reduce the contents of PGE2, TNF-α and IL-1β in the injured soft tissue, and there was no significant difference compared with the original powder.
CONCLUSION
The novel Huoxue plaster has significant analgesic and anti-inflammatory effects, and can be used to treat chronic soft tissue injury. The efficacy of the novel Huoxue plaster is basically the same as that of the original powder.
